Light-controlled electrokinetic assembly of particles near surfaces
First Claim
1. A planar array of beads in a spatially non-random configurition, said array comprising a plurality of different bead types, wherein each of said bead types has a different biomolecule auached thereto for forming a complex with an analyte, and wherein said bead types are encoded with a chemical or physical characteristic that uniquely identifies the biomolecule of said bead type, and wherein said array of beads is configured such that when said array of beads is contacted with liquid comprising an analyte, the beads of saild array ae in a continuous liquid phase.
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Abstract
A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components.
116 Citations
17 Claims
- 1. A planar array of beads in a spatially non-random configurition, said array comprising a plurality of different bead types, wherein each of said bead types has a different biomolecule auached thereto for forming a complex with an analyte, and wherein said bead types are encoded with a chemical or physical characteristic that uniquely identifies the biomolecule of said bead type, and wherein said array of beads is configured such that when said array of beads is contacted with liquid comprising an analyte, the beads of saild array ae in a continuous liquid phase.
Specification