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Methods of characterizing drug activities using consensus profiles

  • US 6,801,859 B1
  • Filed: 12/23/1998
  • Issued: 10/05/2004
  • Est. Priority Date: 12/23/1998
  • Status: Expired due to Term
First Claim
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1. A method of determining a consensus profile for a first plurality of drug perturbations to a cell type or organism, said method comprising determining, for each of a plurality of sets of cellular constituents in a plurality of response profiles, whether said set of cellular constituents is upregulated or downregulate by each of said first plurality of drug perturbations, each response profile in said plurality of response profiles (i) comprising measurements of a plurality of cellular constituents, and (ii) resulting from a different drug perturbation among said first plurality of drug perturbations to said type of cell or organism, wherein each set of cellular constituents in said plurality of sets of cellular constituents consists of cellular constituents that co-vary in the plurality of response profiles, wherein the cellular constituents which co-vary are identified by cluster analysis of cellular constituents in the plurality of response profiles, wherein the cluster analysis is done by means of the clustering algorithm hclust, wherein said plurality of response profiles comprises at least five response profiles, and wherein said consensus profile for said first plurality of drug perturbations consists of measurements of said set or sets of cellular constituents that are determined in said determining step to be upregulated or downregulate by each of said first plurality of drug perturbations.

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