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Self-referencing enzyme-based microsensor and method of use

  • US 6,802,957 B2
  • Filed: 09/28/2001
  • Issued: 10/12/2004
  • Est. Priority Date: 09/28/2001
  • Status: Expired due to Fees
First Claim
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1. A method of determining a flux of an analyte with respect to a source, the method comprising:

  • (a) oscillating an electrode including an enzyme between first and second positions proximal to the source, whereby the enzyme contacts the analyte and generates a species detectable by the electrode, and whereby at each of the positions the concentration of the detectable species is dependent on the concentration of the analyte;

    (b) applying a voltage to a portion of the electrode so that the detectable species undergoes a chemical change to generate a position-dependent current;

    (c) sensing the current at the first and second positions; and

    (d) using the sensed currents to determine the flux of the analyte with respect to the source.

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