Delivery of erectile dysfunction drugs through an inhalation route
First Claim
1. A composition for delivery of an erectile dysfunction drug comprising a condensation aerosola) formed by volatilizing an erectile dysfunction drug under conditions effective to produce a heated vapor of the drug and condensing the heated vapor of the drug to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% erectile dysfunction drug degradation products, and c) the aerosol has an MMAD less than 3 microns.
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Accused Products
Abstract
The present invention relates to the delivery of erectile dysfunction drugs through an inhalation route. Specifically, it relates to aerosols containing erectile dysfunction drugs that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of an erectile dysfunction drug. In a method aspect of the present invention, an erectile dysfunction drug is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of an erectile dysfunction drug, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering an erectile dysfunction drug through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of an erectile dysfunction drug; and, b) a device that forms an erectile dysfunction drug aerosol from the composition, for inhalation by the mammal.
156 Citations
13 Claims
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1. A composition for delivery of an erectile dysfunction drug comprising a condensation aerosol
a) formed by volatilizing an erectile dysfunction drug under conditions effective to produce a heated vapor of the drug and condensing the heated vapor of the drug to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% erectile dysfunction drug degradation products, and c) the aerosol has an MMAD less than 3 microns.
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2. A composition for delivery of sildenafil, tadalafil or vardenafil comprising a condensation aerosol
a) formed by volatilizing sildenafil, tadalafil or vardenafil under conditions effective to produce a heated vapor of sildenafil, tadalafil or vardenafil and condensing the heated vapor of sildenafil, tadalafil or vardenafil to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% sildenafil, tadalafil or vardenafil drug degradation products, and c) the aerosol has an MMAD less than 3 microns.
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6. A method of producing an erectile dysfunction drug in an aerosol form comprising:
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a) volatilizing an erectile dysfunction drug under conditions effective to produce a heated vapor of the drug, and b) during said volatilizing, passing air through the heated vapor to produce aerosol particles of the drug comprising less than 5% erectile dysfunction drug degradation products and an aerosol having an MMAD less than 3 μ
m.- View Dependent Claims (8, 9)
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7. A method of producing sildenafil, tadalafil or vardenafil in an aerosol form comprising
a) volatilizing sildenafil, tadalafil or vardenafil under conditions effective to produce a heated vapor of sildenafil, tadalafil or vardenafil, and b) during said volatilizing, passing air through the heated vapor to produce aerosol particles of the sildenafil, tadalafil or vardenafil comprising less than 5% sildenafil, tadalafil or vardenafil degradation products and an aerosol having an MMAD less than 3 μ
Specification