Detection of biological molecules using chemical amplification and optical sensors
First Claim
1. A system comprising a biocompatible polymer matrix and an amplification component incorporated within the biocompatible polymer matrix that is capable of producing a polyhydroxylated analyze signal upon interrogation by an optical system, wherein said amplification component in covalently attached to said biocompatible polymer matrix and requires a photo-induced electron transfer for production of said signal, and further wherein said biocompatible polymer matrix permeable to glucose.
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Abstract
Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.
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Citations
24 Claims
- 1. A system comprising a biocompatible polymer matrix and an amplification component incorporated within the biocompatible polymer matrix that is capable of producing a polyhydroxylated analyze signal upon interrogation by an optical system, wherein said amplification component in covalently attached to said biocompatible polymer matrix and requires a photo-induced electron transfer for production of said signal, and further wherein said biocompatible polymer matrix permeable to glucose.
- 14. A system comprising a biocompatible polymer matrix and a fluorescent transducer component incorporated within the biocompatible polymer matrix that binds polyhydroxylate analyte and whose fluorescence is modulated by a photo-induced electron transfer process, wherein upon illumination of the fluorescent transducer component in the presence of polyhydroxylate analyte a change in fluorescence is observable that is correlatable with the concentration of bound polyhydroxylate analyte and wherein polyhydroxylate analyte binding to the fluorescent transducer component produces a decrease in the fluorescence of the fluorescent transducer component.
- 19. A system comprising a biocompatible polymer matrix and an amplification component incorporated within the biocompatible polymer matrix that is capable of producing a signal upon interrogation by an optical system, wherein the signal is modulated by polyhydroxylate analyte binding and wherein polyhydroxylate analyte binding modulates a photo-induced electron transfer process, and further wherein bound polyhydroxylate analyte produces a decrease in the signal.
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24. A system comprising a biocompatible polymer matrix having a mesh incorporated therein and in amplification component incorporated within the biocompatible polymer matrix that is capable of producing a polyhydroxylated analyte signal upon interrogation by an optical system, wherein said amplification component requires a photo-induced electron transfer for production of said signal, and further wherein said biocompatible polymer matrix is permeable to glucose.
Specification