Microdialysis probe

• US 6,805,683 B1
• Filed: 05/10/2002
• Issued: 10/19/2004
• Est. Priority Date: 07/14/1999
• Status: Expired due to Fees

• Current Assignee: CMA Microdialysis AB
• Original Assignee: CMA Microdialysis AB
• Inventors: Johansson, Roger
• Primary Examiner(s): Bianco, Patricia
• Application Number:
  US10/030,922
• Time in Patent Office: 893 Days
• Field of Search: 604/4.01, 604/5-1-, 604/6.09, 604/6.16, 604/19, 604/27, 604/28-29, 604/39, 604/43, 604/500, 604/506-508, 604/264, 604/268, 604/523, 604/529, 604/532-35, 210/645-647, 210/650-652, 210/348, 210/321.6, 210/321.61, 210/321.72, 210/321-7-3, 128/898
• US Class Current: 604/6.16
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/14528 invasively
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61M 2025/0042 Microcatheters, cannula or the like having outside diameters around 1 mm or less
• CPC Class Codes: A61M 25/0068 Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
• CPC Class Codes: A61M 25/0069 Tip not integral with tube
• CPC Class Codes: A61M 25/0082 Catheter tip comprising a tool

Abstract

A microdialysis probe includes a dialysis membrane located and supported between a closed distal end of the probe and a proximal end of the same, which membrane essentially-surrounding a space for passage of perfusion liquid. The probe has an inlet and outlet for perfusion liquid. The probe exhibits a deformable mesh sleeve adapted to enclose and protect at least the dialysis membrane, the proximal end of the deformable being fastened to the probe between the proximal end of the probe and the dialysis membrane.

Claims

1. A microdialysis probe, comprising a dialysis membrane (115,215,315,415) located and supported between a closed distal end of the probe and a proximal end of the same, said membrane (115,215,315,415) essentially surrounding a space (118,218,318,418) for passage of perfusion liquid;

said probe having input and output means (107,108;

207,208;

307,308;

407,408) for perfusion liquid;

characterized by a deformable mesh sleeve (120,220,320,420) adapted to enclose and protect at least said dialysis membrane (115,215,315,415) a proximal end of said deformable sleeve fastened to the probe between the proximal end of the probe and the dialysis membrane (115,215,315,415).

2. Microdialysis probe according to claim 1, characterized in that said deformable mesh sleeve (120,220,320,420) being X-ray opaque through the addition of substances to the material forming the deformable mesh sleeve (120,220,320,420) giving the material such characteristics.

3. Microdialysis probe according to claim 2, characterized in that said substance is a metal dispersed in the material forming the deformable mesh sleeve (120,220,320,420).

4. Microdialysis probe according to claim 2, characterized in that said substance is a metal-ion comprised in one of or in the compound of the material forming the deformable mesh sleeve (120,220,320,420).

5. Microdialysis probe according to claim 1, characterized in that said deformable mesh sleeve (120,220) has a closed distal end (120,221) surrounding the distal end (110,210) of the probe.

6. Microdialysis probe according to claim 1, characterized in that said deformable mesh sleeve (320) has a closed distal end unitary with the distal end (310) of the probe.

7. Microdialysis probe according to claim 1, characterized in that said deformable mesh sleeve (420) has an open distal end.

8. Microdialysis probe according to claim 1, characterized in that said deformable mesh sleeve when subjected to a pulling action in the longitudinal direction of the sleeve (120,220,320,420) is deformed such that the diameter of said sleeve decreases.

9. Microdialysis probe according to claim 1, characterized said deformable mesh sleeve (120,220,320,420) being X-ray opaque through the substitution of or inclusion of x-ray opaque filaments in the material making up the mesh material.