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Multiple unit controlled food effect-independent release pharmaceutical preparations and method for preparing the same

  • US 6,805,881 B1
  • Filed: 04/23/2001
  • Issued: 10/19/2004
  • Est. Priority Date: 09/18/1998
  • Status: Expired due to Fees
First Claim
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1. A process for the production of an orally administratable multiple-unit sustained-release pharmaceutical composition having controlled agitation-independent release, consisting essentially of the steps of (a) combining hydroxypropylcellulose polymer having a molecular weight of 250000 to 1200000 and a molar degree of substitution of at least 3 in an amount from 40 to 95% by weight with a pharmaceutically active compound and optionally with one or more pharmaceutically acceptable additional polymers and/or excipients which do not contribute significantly to a sustained-release effect, to obtain a mixture of containing said hydroxypropyl cellulose polymer and said active compound;

  • (b) converting said mixture into particles having a diameter of 0.2 to 3.0 mm;

    (c) optionally lacquering said particles, and (d) incorporating said particles into an orally administratable multi-unit sustained release dosage form.

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