Adherent N,O-Carboxymethylchitosan drug delivery devices for moist tissue and methods of their use

• US 6,809,085 B1
• Filed: 07/06/2000
• Issued: 10/26/2004
• Est. Priority Date: 05/20/1999
• Status: Expired due to Fees

• Current Assignee: Chitogenics, Inc. (Kytogenics Pharmaceuticals, Inc.)
• Original Assignee: Chitogenics, Inc. (Kytogenics Pharmaceuticals, Inc.)
• Inventors: Kydonieus, Agis, Elson, Clive M.
• Primary Examiner(s): Crane, L. E.
• Application Number:
  US09/610,281
• Time in Patent Office: 1,573 Days
• Field of Search: 514/55, 536/20
• US Class Current: 514/55
• CPC Class Codes: A61K 31/722 Chitin, chitosan
• CPC Class Codes: A61L 24/08 Polysaccharides A61L24/043 takes precedence
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 31/042 Polysaccharides
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: C08L 5/08 Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
• CPC Class Codes: C12N 2533/72 Chitin, chitosan
• CPC Class Codes: C12N 5/0068 General culture methods using substrates for specific animal cell type C12N5/06

Abstract

The present invention relates to drug delivery devices for moist tissue, in particular mucosal tissue and tissue in the serous cavities, as well as a method of its use. The devices, which contain NOCC, are adherent to the mucosal tissue, allowing localized drug delivery. The devices are particularly useful in vaginal, buccal and ocular devices.

Claims

1. A method of providing sustained release of a drug to moist tissue comprising applying to said moist tissue a drug delivery device which is adherent to said moist tissue and includes a level of N,O-carboxymethylchitosan as a component thereof to provide said adherence, said drug delivery device further containing a sufficient quantity of the drug to be delivered to provide sustained release of said drug and permeation into said moist tissue or into the surrounding cavity, wherein said moist tissue is mucosal tissue or a tissue in a serous cavity.

2. The method of claim 1, wherein said moist tissue comprises mucosal tissue.

3. The method of claim 2 wherein said mucosal tissue comprises tissue of the oral cavity.

4. The method of claim 3 wherein said oral cavity tissue comprises buccal tissue.

5. The method of claim 4 wherein said drug is selected from the group consisting of melatonin, chlorpheniramine, chlorhexidine, tetracycline and mixtures thereof.

6. The method of claim 3 wherein said device comprises a structural support material selected from the group consisting of rubber, plastic, resin natural and synthetic polymers, and mixtures thereof.

7. The method of claim 2 wherein said mucosal tissue comprises vaginal tissue.

8. The method of claim 7 wherein said drug is selected from a group consisting of progestins, estrogens, antifungal agents, antibacterial agents, anti-viral agents, proteins and peptides.

9. The method of claim 8 wherein said drug comprises levonorgestrel.

10. The method of claim 2 wherein said mucosal tissue comprises ocular tissue.

11. The method of claim 10 wherein said drug is selected from the group consisting of beta blockers and glaucoma treating drugs.

12. The method of claim 2 wherein said mucosal tissue comprises the gastrointestinal tract.

13. The method of claim 1 wherein said moist tissue is tissue in a serous cavity.

14. The method of claim 13 wherein said moist tissue is tissue within the pleural, pericardial or peritoneal cavities.