Methods for therapy of radiation cutaneous syndrome

• US 6,809,118 B2
• Filed: 07/25/2002
• Issued: 10/26/2004
• Est. Priority Date: 07/25/2002
• Status: Expired due to Fees

• Current Assignee: Sunny Pharmtech Inc.
• Original Assignee: Yih-Lin Chung
• Inventors: Chung, Yih-Lin
• Primary Examiner(s): Krass, Frederick
• Assistant Examiner(s): OSTRUP, CLINTON T
• Application Number:
  US10/205,738
• Publication Number:
  US 20040018958A1
• Time in Patent Office: 824 Days
• Field of Search: 514/570, 514/575, 514/557, 514/559, 424/59, 424/60, 424/886, 424/887, 424/925, 424/928
• US Class Current: 514/570
• CPC Class Codes: A61K 31/075 Ethers or acetals
• CPC Class Codes: A61K 31/165 having aromatic rings, e.g. colchicine, atenolol, progabide
• CPC Class Codes: A61K 31/19 Carboxylic acids, e.g. valproic acid salicylic acid A61K31/60
• CPC Class Codes: A61K 31/545 Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula: , e.g. cephalosporins, cefaclor, or cephalexine
• CPC Class Codes: A61K 38/15 Depsipeptides; Derivatives thereof
• CPC Class Codes: A61K 9/06 Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels composition of ointments, creams or gels A61K47/00
• CPC Class Codes: A61K 9/127 Liposomes

Abstract

Compounds of a histone deacetylase inhibitor. The compounds are capable of simultaneously stimulating epithelium regrowth, inhibiting cutaneous fibroblast proliferation, decreasing collagen deposit, suppressing fibrogenic growth factor and subsiding inflammatory cytokine, and are useful inhibiting the main features of radiation cutaneous syndrome. Results include a decrease in skin swelling, promotion of epithelium healing, and prevention of cutaneous fibrosis, ulceration and necrosis. The present invention provides methods of treating, preventing or ameliorating radiation-induced skin damage by administering a therapeutically effective amount of a histone deacetylase inhibitor.

Claims

1. A method for treating radiation-induced skin damage, comprising administration to humans or animals in need of treatment for radiation-induced dermatitis, desquamation, fibrosis, ulceration, or necrosis a therapeutically effective amount of a pharmaceutical composition comprising a histone deacetylase inhibitor and a pharmaceutically acceptable carrier or a pharmaceutically acceptable salt thereof.

2. The method as claimed in claim 1, wherein the histone deacetylase inhibitor is present in an amount from 0.1 to 50% by weight of the compositions.

3. The method as claimed in claim 1, wherein the histone deacetylase inhibitor is present in an amount from 0.01 to 100 mg of the histone deacetylase inhibitor.

4. The method as claimed in claim 1, wherein the histone deacetylase inhibitor comprises valproic acid or a pharmaceutically acceptable salt thereof.

5. The method as claimed in claim 1, wherein the histone deacetylase inhibitor comprises trichostatin A or a pharmaceutically acceptable salt thereof.

6. The method as claimed in claim 1, wherein the histone deacetylase inhibitor comprises phenylbutyrate or a pharmaceutically acceptable salt thereof.

7. The method as claimed in claim 1, wherein the histone deacetylase inhibitor comprises depudecin or a pharmaceutically acceptable salt thereof.

8. The method as claimed in claim 1, wherein the histone deacetylase inhibitor comprises trapoxin A or a pharmaceutically acceptable salt thereof.

9. The method as claimed in claim 1, wherein the histone deacetylase inhibitor comprises depsipeptide or a pharmaceutically acceptable salt thereof.

10. The method as claimed in claim 1, wherein the histone deacetylase inhibitor comprises oxamflatin or a pharmaceutically acceptable salt thereof.

11. The method as claimed in claim 1, wherein the histone deacetylase inhibitor comprises benzamide or a pharmaceutically acceptable salt thereof.

12. The method as claimed in claim 1, wherein the pharmaceutical composition is administered non-orally.

13. The method as claimed in claim 12, wherein the composition is a cream, an ointment, a gel, a lotion, a patch, a suppository, a powder form, a liposome formation, an injection solution, or a drip infusion.