Microdialysis probe and catheter arrangement

• US 6,811,542 B2
• Filed: 06/24/2002
• Issued: 11/02/2004
• Est. Priority Date: 06/24/2002
• Status: Expired due to Fees

• Current Assignee: Maquet Critical Care AB (Getinge AB)
• Original Assignee: Anders Franco-Cereceda, Jan Liska
• Inventors: Franco-Cereceda, Anders, Liska, Jan
• Primary Examiner(s): Nguyen, Anhtuan T.
• Application Number:
  US10/177,108
• Publication Number:
  US 20030236454A1
• Time in Patent Office: 862 Days
• Field of Search: 604/29, 604/43, 604/513, 604/167.07, 604/167.01, 604/167.02, 604/523
• US Class Current: 604/29
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/14528 invasively

Abstract

A microdialysis probe and catheter arrangement includes a catheter carrying in a distal end thereof a probe to be inserted in the body of a living being. The catheter has an elongate catheter body including a first channel for supplying a first fluid and a second channel for returning said first fluid. The first and second channels extend internally along the catheter body from a proximal end thereof to the probe. The probe includes a microdialysis membrane defining a dialysis chamber communicating with the first and second channels. A third channel extends internally along the catheter body and communicates with the second channel to supply a second fluid to thereto, thereby to increase the flow rate therein.

Claims

1. A microdialysis probe and catheter arrangement comprising:

a catheter carrying in a distal end thereof a probe to be inserted in the body of a living being, said catheter having an elongate catheter body including a first channel for supplying a first fluid and a second channel for returning said first fluid, said first and second channels extending internally within said catheter body from a proximal end thereof to at least said probe, said probe including a microdialysis membrane defining a dialysis chamber communicating with said first and second channels,

wherein a third channel extends internally within said catheter body from a proximal end thereof to at least said probe and communicates with said second channel at a point adjacent to a distal end of the microdialysis chamber in order to supply a second fluid to said second channel.

2. The microdialysis probe and catheter arrangement according to claim 1, wherein said first and second channels communicate with said microdialysis chamber by means of a first and a second cross channel, respectively, extending through said catheter body from the respective first and second channel to its exterior wall.

3. The microdialysis probe and catheter arrangement according to claim 1, wherein said third channel communicates with said second channel by means of a third cross channel extending through said catheter body.

4. The microdialysis probe and catheter arrangement according to claim 3, wherein said second and third cross channels are aligned.

5. The microdialysis probe and catheter arrangement according to claim 3, wherein said second and third cross channels are not aligned.

6. The microdialysis probe and catheter arrangement according to claim 1 wherein the first channel, the second channel, and the third channel are arranged inside the catheter body along a common diametrical plane.

7. The microdialysis probe and catheter arrangement according to claim 1, wherein the first channel, the second channel, and the third channel have equal, circular cross sections.

8. The microdialysis probe and catheter arrangement according to claim 1, wherein the microdialysis chamber surrounds an exterior wall of the catheter body, and the first channel, the second channel, and the third channel which extend parallel to each other within the catheter body.

9. A method of performing a microdialysis process, comprising the steps of:

feeding a first liquid from a proximal end of a catheter through a first channel extending internally along said catheter;

introducing said first liquid into a microdialysis chamber provided at a distal end of said catheter;

returning said first liquid together with samples collected in said microdialysis chamber to said proximal end through a second channel extending internally along said catheter;

directing a flow of a second liquid from a third channel extending internally along said catheter into said second channel to increase the flow rate therein, the second channel and the third channel each being formed inside a body of the catheter and extending from a proximal end to a distal end thereof, and communicating with each other at a point adjacent to a distal end of the microdialysis chamber.

10. The method according to claim 9, wherein said second liquid is continuously directed into said second channel.

11. The method according to claim 9, wherein said second liquid is intermittently directed into said second channel.

12. The method according to claim 9, returning said first liquid together with the samples collected in said microdialysis chamber through said second channel which communicates with the microdialysis chamber via a cross channel opening to the distal end of the microdialysis chamber.