Apparatus for the operation of a microfluidic device

• US 6,811,668 B1
• Filed: 06/15/2000
• Issued: 11/02/2004
• Est. Priority Date: 06/22/1999
• Status: Expired due to Term

• Current Assignee: Agilent Technologies, Inc., Caliper Life Sciences Incorporated (Revvity, Inc.)
• Original Assignee: Caliper Life Sciences Incorporated (Revvity, Inc.)
• Inventors: Kennedy, Colin B., Berndt, Manfred, Kaltenbach, Patrick
• Primary Examiner(s): Bell, Mark L.
• Assistant Examiner(s): BROWN, JENNINE M
• Application Number:
  US09/595,420
• Time in Patent Office: 1,601 Days
• Field of Search: 204/601
• US Class Current: 204/601
• CPC Class Codes: B01L 2200/027 for microfluidic devices
• CPC Class Codes: B01L 2200/10 Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
• CPC Class Codes: B01L 2300/0819 Microarrays; Biochips
• CPC Class Codes: B01L 2400/0421 electrophoretic flow
• CPC Class Codes: B01L 3/502715 characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces

Abstract

In a system for operation or handling of a laboratory microchip (41) for chemical processing or analysis, the microchip (41) is mounted in a first physical unit (42). The microchip (41) is arranged on a mounting plate, such that it is readily accessible from the top and thus the fitting and removal of the microchip is considerably simplified. Furthermore, the first physical unit (42) comprises an optical device (43) for contactless detection of the results of the chemical processes conducted on the microchip. The supply systems necessary for the operation of the microchip are arranged in a module unit that has a separable connection with a second physical unit. The proposed modular layout enables ease of interchangeability of the required supply systems and thus, overall, ease of adaptability of the proposed system for various types of microchips.

Claims

1. A system for analysis or synthesis of materials, comprising:

a first physical unit, comprising a mounting region for receiving a microfluidic device;

at least one second physical unit spatially separated from the first physical unit and comprising a material transport system that includes at least a first interface component;

wherein the first physical unit and second physical unit are oriented with respect to each other whereby the material transport system provides a potential to the microfluidic device through the first interface component to transport material through the microfluidic device; and

wherein the first interface component is removable from the second physical unit.

2. The system of claim 1, wherein the material transport system is oriented within the second physical unit to provide at least one fluid to the microfluidic device in the mounting region of the first physical unit.

3. The system of claim 2, wherein the first interface component and the material transport system comprise at least one common conduit disposed in the second physical unit, the at least one conduit providing both a potential for moving material and at least a first fluid to the microfluidic device.

4. The system of claim 1, further comprising a control unit operably coupled to the first interface component for controlling application of the potential to the microfluidic device.

5. The system of claim 3, further comprising a control unit operably coupled to the material transport system, for controlling supply of fluid to the microfluidic device.

6. The system of claim 1, wherein the first interface component comprises a sensor for measuring an electrical voltage within the microfluidic device.

7. The system of claim 1, further comprising at least a second interface component, the second interface component providing at least one of potential and fluid to the microfluidic device.

8. The system of claim 7, wherein the second interface component is removably attached to the second physical unit.

9. The system of claim 8, wherein the second interface component is mounted on the first interface component by a bayonet fitting.

10. The system of claim 1, wherein the first physical unit further comprises a detector disposed therein, the detector being positioned to detect signals from the microfluidic device on the mounting region.

11. The system of claim 1, wherein the mounting region is open from the top for placing a microfluidic device on the mounting region.

12. The system of claim 1, further comprising a microfluidic device received in the mounting region of the first physical unit.

13. The system of claim 1, wherein the material transport system is arranged within a module unit which is separably connectable with the second physical unit.