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Retentate chromatography—profiling with biospecific interaction adsorbents

  • US 6,811,969 B1
  • Filed: 06/23/2000
  • Issued: 11/02/2004
  • Est. Priority Date: 06/20/1997
  • Status: Expired due to Term
First Claim
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1. A method for detecting polypeptide analytes in a sample, the method comprising the steps of:

  • a) exposing the sample to between 10-10,000 different selectivity conditions at different addressable locations, each selectivity condition defined by a combination of a biospecific interaction adsorbent comprising a polypeptide and an eluant, and wherein exposing comprises (I) contacting the sample with a biospecific interaction adsorbent bound to a substrate, and (II) washing unbound polypeptides from the biospecific interaction adsorbent with the eluant to allow retention of polypeptide analytes on the biospecific interaction adsorbent; and

    b) detecting retained polypeptide analytes on each biospecific interaction adsorbent by laser desorption mass spectrometry from each substrate at different addressable locations.

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