Dye desortion molecular indicator
First Claim
1. A broad screen analytical detection element, capable of detection of several classes of gas or liquid analytes, said detection element comprisinga first region comprising a solid and adsorbed said solid a radiant energy-detectable material or a material capable of producing a radiant energy-detectable material, wherein said radiant energy-detectable material or said material capable of producing a radiant energy-detectable material is desorbable by a target analyte;
- and a second region for sequestering radiant energy-detectable material (a) desorbed from or (b) produced by material desorbed from said solid prior to detection of said radiant energy-detectable material, wherein either said first region or said second region further comprises a high boiling plasticizer/solvent and wherein classes of gas or liquid analytes are detected.
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Abstract
A method of broad screen detection, competitive dye desorption from a solid adsorbent, is described for quantifying the presence of a molecule or target analyte in the vapor phase, in solution, or eluted from a solid. In the function of an analytical element for implementing the competitive dye desorption method of the invention, dye or dye-precursor molecules adsorbed on the surface of an adsorbent are caused to desorb through the adsorption of the target analyte on the adsorbent. The desorbed dye or precursor is made detectable through sequestering of a radiation detectable species in the device of the invention. Such detection may occur, e.g., through absorption or emission of radiation in regions of the spectrum extending from the ultra-violet through the visible and into the infra-red regions. In one aspect of the invention, these processes occur within a multi-layer analytical element, in which the functions of the device may be executed by different layers.
45 Citations
22 Claims
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1. A broad screen analytical detection element, capable of detection of several classes of gas or liquid analytes, said detection element comprising
a first region comprising a solid and adsorbed said solid a radiant energy-detectable material or a material capable of producing a radiant energy-detectable material, wherein said radiant energy-detectable material or said material capable of producing a radiant energy-detectable material is desorbable by a target analyte; - and
a second region for sequestering radiant energy-detectable material (a) desorbed from or (b) produced by material desorbed from said solid prior to detection of said radiant energy-detectable material, wherein either said first region or said second region further comprises a high boiling plasticizer/solvent and wherein classes of gas or liquid analytes are detected. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A broad screen analytical detection element, capable of detection of several classes of gas or liquid analytes, said detection element comprising
a first region comprising a solid and adsorbed on said solid a radiant energy-detectable material or a material capable of producing a radiant energy-detectable material, wherein said radiant energy-detectable material or said material capable of producing a radiant energy-detectable material is desorbable by a target analyte; - and
a second region for sequestering radiant energy-detectable material desorbed from or produced by material desorbed from said solid prior to detection of said radiant energy-detectable material, wherein said detection element is in the form of multiple small pieces and wherein classes of gas or liquid analytes are detected.
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14. A broad screen method for detection of one or more analytes or classes of analytes, said method comprising the steps of:
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providing an analytical detection element, said detection element comprising a solid and adsorbed on said solid a radiant energy-detectable material or a material capable of producing a radiant energy-detectable material, wherein said radiant energy-detectable material or said material capable of producing a radiant energy-detectable material is desorbable by a target analyte;
exposing said analytical detection element to a population of molecules possibly containing said target analytes for a period of time sufficient to permit desorption by said target analytes of said radiant energy-detectable material or said material capable of producing a radiant energy-detectable material from said solid, wherein said radiant energy-detectable material or said material capable of producing a radiant energy-detectable material desorbed by said target analyte is made mobile by the presence of a high boiling plasticizer/solvent;
determining the amount of said radiant energy-detectable material or said material capable of producing a radiant energy-detectable material desorbed from said solid; and
correlating the amount of said radiant energy-detectable material or said material capable of producing a radiant energy-detectable material desorbed from said solid with the amount of target analyte present in said population of molecules. - View Dependent Claims (15, 16, 17, 18, 19, 22)
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20. A broad screen analytical detection element, capable of detection of several classes of gas or liquid analytes, said detection element comprising a first region comprising
(a) a solid and adsorbed on said solid a radiant energy-detectable material or a material capable of producing a radiant energy-detectable material, wherein said radiant energy-detectable material or said material capable of producing a radiant energy-detectable material is desorbable by a target analyte, and (b) a high boiling plasticizer/solvent, wherein several classes of gas or liquid analytes are detected.
Specification