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Method and apparatus for MALDI analysis

  • US 6,812,455 B2
  • Filed: 04/03/2002
  • Issued: 11/02/2004
  • Est. Priority Date: 09/19/1996
  • Status: Expired due to Fees
First Claim
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1. An apparatus for matrix assisted laser desorption of a large molecule analyte, such apparatus comprising:

  • a support stage; and

    an optical fiber, wherein;

    the support stage includes a means for holding a sample on a substrate in a defined region of the stage and is adapted to hold the optical fiber; and

    the optical fiber includes a first end adapted to couple to a light source for receiving a light input, and a second end held by said stage in a position to illuminate a spot region on the sample, the stage positioning the second end so that its output beam passes through the substrate to directly illuminate said spot region on the sample with a spot of defined size at a fluence effective to desorb the analyte from the sample.

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