Detection of metabolic dysfunctions using fluorescence emission from serum
First Claim
1. A method for the diagnosis of a disease of metabolic dysfunction, comprising:
- obtaining a sample of serum from a patient;
irradiating the sample with a plurality of irradiation wavelengths from about 300 to about 340 nm simultaneously;
measuring the serum emission at one or more wavelengths from about 300 to about 600 nm; and
diagnosing the presence of a metabolic dysfunction by an increased or decreased emission in comparison to an average emission at said wavelength of serum of a plurality of normal healthy volunteers.
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Abstract
Serum emission can be used as the first test to detect metabolic disorders in mammals. When changes in emission of the serum from patients with different pathological conditions were characterized, a difference was seen for patients with diseases such as cancer, thyroid disorder, arthritis, diabetes, coronary artery disease (CAD), hypertension, CFS (chronic fatigue syndrome), and fibromyalgia. The level of emission was enhanced or diminished and correlated with the level of energy metabolism and the level of metabolic rate. The method can also be used for risk assessment, to identify whether a treatment is working or to follow the course of a treatment, and to identify changes in energy levels due to stress, etc.
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Citations
31 Claims
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1. A method for the diagnosis of a disease of metabolic dysfunction, comprising:
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obtaining a sample of serum from a patient;
irradiating the sample with a plurality of irradiation wavelengths from about 300 to about 340 nm simultaneously;
measuring the serum emission at one or more wavelengths from about 300 to about 600 nm; and
diagnosing the presence of a metabolic dysfunction by an increased or decreased emission in comparison to an average emission at said wavelength of serum of a plurality of normal healthy volunteers. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. A method for analysis of the effectiveness of a treatment, comprising:
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obtaining a first sample of serum from a patient before the treatment;
irradiating the first sample at more than one irradiation wavelength from about 300 to about 340 nm simultaneously;
measuring the serum emission at at least one emission wavelength from about 300 to about 600 nm;
obtaining a second sample of serum from a patient after the treatment, wherein said patient has fasted for at least about 8 hours prior to obtaining the first sample;
irradiating the second sample at more than one irradiation wavelength from about 300 to about 340 nm simultaneously;
measuring the serum emission at at least one emission wavelength from about 300 to about 600 nm; and
diagnosing the effectiveness of the treatment by an increased or decreased emission in the second sample relative to the first sample. - View Dependent Claims (27, 28, 29, 30, 31)
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Specification