Device to operate a laboratory microchip

• US 6,814,846 B1
• Filed: 06/22/2000
• Issued: 11/09/2004
• Est. Priority Date: 06/22/1999
• Status: Expired due to Fees

• Current Assignee: Agilent Technologies, Inc.
• Original Assignee: Agilent Technologies, Inc.
• Inventors: Berndt, Manfred
• Primary Examiner(s): Bell, Mark L.
• Assistant Examiner(s): BROWN, JENNINE M
• Application Number:
  US09/598,968
• Time in Patent Office: 1,601 Days
• Field of Search: 204/601
• US Class Current: 204/601
• CPC Class Codes: B01J 19/0093 Microreactors, e.g. miniaturised or microfabricated reactors laboratory containers with capillary fluid transport in microfabricated channels or chambers B01L3/5027
• CPC Class Codes: B01J 2219/00891 Feeding or evacuation
• CPC Class Codes: B01J 2219/00952 Sensing operations
• CPC Class Codes: B01L 2200/027 for microfluidic devices
• CPC Class Codes: B01L 2300/0663 Whole sensors
• CPC Class Codes: B01L 2300/0816 Cards, e.g. flat sample carriers usually with flow in two horizontal directions
• CPC Class Codes: B01L 2400/0415 electrical forces, e.g. electrokinetic
• CPC Class Codes: B01L 9/527 for microfluidic devices, e.g. used for lab-on-a-chip

Abstract

In a device to operate and handle a laboratory microchip to chemically process or analyze substances, the microchip is on a chip holder (41) that is part of a first assembly (42). The first assembly (42) also has an optical device (43) for contactless detection of the results of the chemical processes carried out on the microchip. A supply device (56) required to operate the microchip is in a module releasably connected to a second assembly (44, 55). In particular, the second assembly (44, 55) has an intermediate carrier (57) that is releasably connected to the supply device (56). The intermediate carrier has continuous electrical paths (60) or connecting channels that can bridge electrodes (58) or supply channels of the supply device (56) and the assigned counterelectrodes (53) of the microchip. There are correspondingly connecting lines (61) to bridge the supply of materials. On the one hand, the bridging serves to prevent wear and soiling of the supply device (56) electrodes that arises upon contacting the microchip. In addition, the intermediate carrier also serves to spatially adapt the electrodes of the supply device (56) to the respective surface or spatial arrangement of the electrode surfaces of the microchip. It is thereby advantageously possible to adapt the entire measuring or operating device to special microchip layouts merely by exchanging the intermediate carrier (57).

Claims

1. A device for operating a microchip with a microfluid structure for chemical, physical, and/or biological processing, the microchip including supply elements corresponding with the microfluid structure, comprising

a supply unit for providing a potential for moving substances corresponding to the microfluid structure, the supply unit having supply lines for enabling the potential to be coupled to the microchip, the supply lines being arranged to interact with the supply elements which correspond to the microfluid structure,

an interface element, and

a holder for carrying the interface element,

the interface element including a structure for connecting the supply lines with at least one of the supply elements that correspond to the microfluid structure,

the interface element and the holder having structures for enabling the interface element to be releasably connectable to the holder so that the interface element can be selectively secured to and removed from the holder,

the interface element having exterior surfaces resistant to the substances processed by the microchip

and further including a magnet/Hall sensor pair, the second assembly including elements mounted on the module, and an output device responsive to a Hall sensor of the magnet/Hall sensor pair.

2. The device according to claim 1, wherein the interface element has electrodes for supplying the microchip with electrical energy for generating a potential required for the microfluid movement of the substances on the microchip.

3. The device according to claim 1, wherein the interface element has channels for supplying the microchip with mechanical energy for generating a potential required for the microfluid movement of the substances on the microchip.

4. The device according to claim 1, wherein the interface element has channels for supplying the microchip with thermal energy for generating a potential required for the microfluid movement of the substances on the microchip.

5. The device according to claim 2, wherein the interface element has channels for supplying the microchip with thermal energy for generating a potential required for the microfluid movement of the substances on the microchip

the channels are arranged for supplying the microchip with mechanical energy for feeding a pressurized fluid.

6. The device according to claim 1, wherein the device is arranged for analyzing or synthesizing substances supplying the microchip with at least some of the necessary substances for processing or analysis, wherein the interface element has channels for supplying the microchip with these substances.

7. The device according to claim 6, further including seals at the ends of the channels of the interface element for preventing the substances from exiting.

8. The device according to claim 1, wherein the interface element includes an electrically insulating substrate in which the electrodes and channels are embedded.

9. The device according to claim 8, wherein the substrate is a ceramic.

10. The device according to claim 8, wherein the substrate is a polymer.

11. The device according to claim 1, wherein the interface element and the supply unit are arranged and constructed so the interface is releasably attached to the supply unit.

12. The device according to claim 11, wherein the interface element includes a bayonet lock for releasably attaching the interface unit to the supply unit.

13. The device according to claim 1, wherein the interface element and the supply unit respectively include a first coding element for identifying the interface element, a second coding element on at least one of the supply units and the microchip, the first and second coding elements corresponding with each other and interacting with each other.

14. The device according to claim 1, wherein the microchip is in a first assembly, and the supply unit as well as the interface element are in a module, a second assembly, the module and second assembly being arranged and constructed so the module is releasably connected to the second assembly.

15. The device according to claim 1, wherein the output device includes a shut-off for the device for operating the laboratory microchip.

16. The device according to claim 1, wherein the output device includes a warning device.

17. The device according to claim 1 wherein the cooperating structures are such that the interface element is locked in place on a securing structure of the holder in response to rotation of the interface element relative to the holder.