Detection method
First Claim
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1. A method for detecting a substance or substances in a sample or in a matrix of samples, comprising the steps of:
- (a) separating the substance or substances to be detected from the sample or matrix of samples with one of an integrated optical (bio)chemo-sensitive sensor-chip plate, of an integrated optical (bio)chemo-sensitive micro-array and of an integrated optical (bio)chemo-sensitive lab-on-chip, wherein each of said integrated optical (bio)chemo-sensitive sensor-chip plate, of said integrated optical (bio)chemo-sensitive micro-array and of said integrated optical (bio)chemo-sensitive lab-on-chip comprises at least one (bio)chemo-sensitive waveguide grating structure unit or (bio)chemo-sensitive sensor location;
(b) detecting during or after the separation the substance or the substances with the help of a light wave, said light wave having an evanescent field and being at least partly guided in a waveguide structure;
(c) detecting the substance or the substances or substance parts on selected (biochemo-sensitive waveguide grating structure units or on selected (bio)chemo-sensitive sensor locations by desorption and ionization of the substance or the substances or the substance parts with the help of a mass spectrometer.
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Abstract
A method for detecting a substance or substances in a sample or in a matrix of samples combining detection methods that are, on the one hand, based on direct detection with integrated optical (bio)chemo-sensitive waveguide grating structures and, on the other hand, based on a mass-spectrometric detection effected by way of a desorption process. The method permits an increase in detection security and/or detection sensitivity.
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Citations
19 Claims
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1. A method for detecting a substance or substances in a sample or in a matrix of samples, comprising the steps of:
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(a) separating the substance or substances to be detected from the sample or matrix of samples with one of an integrated optical (bio)chemo-sensitive sensor-chip plate, of an integrated optical (bio)chemo-sensitive micro-array and of an integrated optical (bio)chemo-sensitive lab-on-chip, wherein each of said integrated optical (bio)chemo-sensitive sensor-chip plate, of said integrated optical (bio)chemo-sensitive micro-array and of said integrated optical (bio)chemo-sensitive lab-on-chip comprises at least one (bio)chemo-sensitive waveguide grating structure unit or (bio)chemo-sensitive sensor location;
(b) detecting during or after the separation the substance or the substances with the help of a light wave, said light wave having an evanescent field and being at least partly guided in a waveguide structure;
(c) detecting the substance or the substances or substance parts on selected (biochemo-sensitive waveguide grating structure units or on selected (bio)chemo-sensitive sensor locations by desorption and ionization of the substance or the substances or the substance parts with the help of a mass spectrometer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification