Method and apparatus for identifying spectral artifacts
First Claim
1. A method of determining whether spectral data obtained from a region of a tissue sample are affected by an artifact, said method comprising the steps of:
- obtaining a first set of spectral data corresponding to a region of a tissue sample using light incident to said region at a first angle;
obtaining a second set of spectral data corresponding to said region using light incident to said region at a second angle; and
determining whether said first set of data is affected by an artifact based at least in part on a subset of said first set of data and a subset of said second set of data.
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Abstract
The invention provides an apparatus and methods for determining whether spectral data obtained from a region of a tissue sample are affected by an artifact. Artifacts include, for example, lighting artifacts such as glare and shadow and obstruction artifacts, such as blood, a speculum, a smoke tube, or other obstruction. Additionally, the invention provides an apparatus and methods for obtaining redundant spectral data of a given region of a sample. A redundant set of spectral data is useful where one or more artifacts affect some but not all sets of the spectral data, such that the redundant set of data is unaffected by the artifact and is representative of the tissue. An embodiment of the invention comprises using representative spectral data in diagnosing a condition of a region of tissue.
250 Citations
39 Claims
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1. A method of determining whether spectral data obtained from a region of a tissue sample are affected by an artifact, said method comprising the steps of:
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obtaining a first set of spectral data corresponding to a region of a tissue sample using light incident to said region at a first angle;
obtaining a second set of spectral data corresponding to said region using light incident to said region at a second angle; and
determining whether said first set of data is affected by an artifact based at least in part on a subset of said first set of data and a subset of said second set of data. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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31. A method of determining whether spectral data corresponding to a region of a tissue sample is affected by an artifact, said method comprising the steps of:
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obtaining a first set of reflectance spectral data corresponding to a region of a tissue sample using light incident to said region at a first angle;
obtaining a second set of reflectance spectral data corresponding to said region using light incident to said region at a second angle;
obtaining a set of fluorescence spectral data corresponding to said region; and
determining whether any of said first set of reflectance spectral data, said second set of reflectance spectral data and said set of fluorescence spectral data are affected by an artifact based at least in part on at least one of the following;
a subset of said first set of reflectance spectral data, a subset of said second set of reflectance spectral data, and a subset of said set of fluorescence spectral data.- View Dependent Claims (32)
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33. A method of determining a spectral characteristic of an artifact, said method comprising the steps of:
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(a) at each of a first plurality of regions of tissue, obtaining a first set of reflectance spectral data affected by a known artifact;
(b) at each of a second plurality of regions of tissue, obtaining a second set of reflectance spectral data not affected by said known artifact; and
(c) determining a spectral characteristic of said known artifact based at least in part on said first set of spectral data and said second set of spectral data. - View Dependent Claims (34, 35, 36, 37, 39)
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38. A method of determining a characteristic of a region of a tissue sample, said method comprising the steps of:
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(a) obtaining a first set of reflectance spectral data corresponding to a region of a tissue sample using light incident to said region at a first angle;
(b) obtaining a second set of reflectance spectral data corresponding to said region using light incident to said region at a second angle;
(c) determining whether at least one of said first set of reflectance data and said second set of reflectance data is affected by an artifact based at least in part on a subset of said first set of reflectance data and a subset of said second set of reflectance data;
(d) rejecting at least one member of at least one of said first set of reflectance data and said second set of reflectance data determined in step (c) to be affected by said artifact; and
(e) determining a characteristic of said region of said tissue sample based at least in part on at least one member of at least one of said first set of reflectance data and said second set of reflectance data not rejected in step (d).
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Specification