Electrochemical sensor with increased reproducibility

• US 6,821,400 B2
• Filed: 06/06/2001
• Issued: 11/23/2004
• Est. Priority Date: 06/07/2000
• Status: Expired due to Fees

• Current Assignee: Asulab SA (The Swatch Group AG)
• Original Assignee: Asulab SA (The Swatch Group AG)
• Inventors: Jaeger, Gérard
• Primary Examiner(s): Olsen, Kaj K.
• Application Number:
  US09/874,035
• Publication Number:
  US 20010050228A1
• Time in Patent Office: 1,266 Days
• Field of Search: 204/403.01, 204/403.02, 204/403.03, 204/403.04
• US Class Current: 204/403.02
• CPC Class Codes: C12Q 1/001 Enzyme electrodes
• CPC Class Codes: G01N 27/3272 Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels optical biosensors G01N33/52

Abstract

The invention concerns a sensor allowing the concentration of a constituent to be determined and being formed by a tongue of small dimensions including a thin plastic substrate (1) supporting at least two current conducting strips (4, 5) separated by a narrow insulating strip (3) of the substrate (1), said substrate (1) and said strips (4, 5) being covered with a plastic covering (2) into which are cut, at one end an opening (8) allowing portions of strip (4, 5) to appear for connection to an electronic apparatus and at the other end two windows (9a, 9b) separated by a strip (11) of the covering (2), said windows (9a, 9b) delimiting on the strips (4, 5) the useful surfaces of a reference electrode beneath a first window (9b) and a measuring electrode beneath a second window (9a) covered with a specific reactant. It is characterised in that at least the measuring window (9a) has an oblong contour in the direction of the tongue.

Application to a glucose sensor in which the specific reactant contains at least glucose oxidase (GOD) and a mediator.

Claims

1. An electrochemical sensor for determining the concentration of a constituent present in a solution or in a liquid of natural or biological origin, formed by a tongue including a thin plastic substrate supporting at least two current conducting strips separated by a narrow insulating strip of the substrate, said substrate and said conducting strips being covered with a plastic covering into which are cut, at one end, an opening allowing portions of said conducting strip to appear for connection to an electronic apparatus, and, close to the other end, two windows laterally separated by a strip of the plastic covering, said windows delimiting on the conducting strips the useful surfaces of a reference electrode beneath a first reference window and a measuring electrode beneath a second measuring window coated with a reagent of the constituent whose concentration one wishes to determine, wherein at least the measuring window has a rounded elongated contour along a length of the tongue, and

wherein said strip of the plastic covering has substantially uniform lateral width over the length of the two windows.

2. An electrochemical sensor according to claim 1, wherein the reference window also has a rounded elongated contour along the length of the tongue.

3. An electrochemical sensor according to claim 2, wherein the measuring window and the reference window are symmetrical with respect to the narrow insulating strip separating the conducting strips, and have a coffee bean configuration.

4. An electrochemical sensor according to claim 1 for determining the level of glucose in the blood, wherein the reagent contains at least glucose oxidase and a chemical mediator able to transfer electrons.

5. An electrochemical sensor according to claim 4, wherein the mediator is selected from among the mono, bis or his 2-2′

ruthenium, osmium or vanadium bipyridine complexes in which at least one of the bipyridine ligands is substituted by at least one electron donor group.