Measuring apparatus and a measuring method for the determination of parameters of medical fluids

• US 6,821,432 B2
• Filed: 08/29/2002
• Issued: 11/23/2004
• Est. Priority Date: 09/03/2001
• Status: Expired due to Term

• Current Assignee: Fresenius Medical Care Deutschland GmbH (Fresenius Medical Care AG)
• Original Assignee: Fresenius Medical Care Deutschland GmbH (Fresenius Medical Care AG)
• Inventors: Metzner, Klaus
• Primary Examiner(s): DRODGE, JOSEPH W
• Application Number:
  US10/230,227
• Publication Number:
  US 20030042181A1
• Time in Patent Office: 817 Days
• Field of Search: 210/85, 210/94, 210/96.1, 210/96.2, 210/645, 210/646, 210/739, 210/745, 337/06, 337/08, 73/10.2, 73/11.6, 73/13.7, 73/17.9, 738/661, 738/665, 356/3, 356/39, 356/300, 356/317, 422/68.01, 422/82.05, 422/82.08, 422/82.09, 422/68.1, 436/8, 436/68, 436/164, 436/165, 436/172
• US Class Current: 210/646
• CPC Class Codes: A61M 1/3609 Physical characteristics of the blood, e.g. haematocrit, urea
• CPC Class Codes: A61M 1/3622 with a cassette forming partially or totally the blood circuit
• CPC Class Codes: A61M 1/3639 Blood pressure control, pressure transducers specially adapted therefor
• CPC Class Codes: A61M 2205/123 with incorporated reservoirs
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: A61M 2230/207 hematocrit

Abstract

A measuring apparatus for the determination of parameters of medical fluids with a measured region which including a measuring chamber device for receiving a disposable cassette with at least one measuring chamber through which the fluid to be measured is guided, and at least one measuring element for measuring a measured value whose value depends on the extent of the measuring chamber in a measuring direction and allows the determination of the parameter, or of a value being in a fixed relationship thereto, with a known extent of the measuring chamber. A distance sensor unit is provided which is arranged relative to the measuring chamber such that the measured distance changes relative to the extent of the measuring chamber. A method is also provided for the determination of parameters of medical fluids which can be carried out with the measuring apparatus, and for the calibration of the measuring apparatus.

Claims

1. A measuring apparatus for the determination of a parameter of a medical fluid with a measured region which comprises the following:

a measuring chamber device for receiving a disposable cassette with at least one measuring chamber through which the fluid to be measured is guided;

at least one measuring element for measuring a measured value whose value depends on an extent of the measuring chamber and allows for determination of the parameter, or of a value being in a fixed relationship thereto, with a known value for said extent of the measuring chamber, and

at least one distance sensor unit which is arranged relative to the measuring chamber device such that a distance measured by said distance sensor unit changes relative to the extent of the measuring chamber.

2. A measuring apparatus in accordance with claim 1, wherein the at least one distance sensor unit includes at least two parts which do not contact one another and which are arranged relative to the measuring chamber device such that a distance between said two parts changes with the extent of the measuring chamber.

3. A measuring apparatus in accordance with claim 1, wherein the distance sensor unit includes at least one device for generation of an electrical and/or magnetic field and at least one sensor for measurement of the generated magnetic and/or electrical field or a change therein.

4. A measuring apparatus in accordance with claim 3, wherein the field generation device includes a least one permanent magnet for generation of a magnetic field and the field sensor includes a magneto-resistive sensor.

5. A measuring apparatus in accordance with claim 1, wherein the measuring element includes an ultrasonic transmitter and an ultrasonic receiver which are arranged with respect to the measuring chamber so as to allow an ultrasonic run time measurement to be taken through the measuring chamber.

6. A measuring apparatus in accordance with claim 1, wherein the apparatus is suitable for use in haemo-dialysis and for determination of blood parameters.

7. A measuring apparatus in accordance with claim 1, wherein the apparatus is suitable for determination of density and/or concentration and/or haemocrit value of the medical fluid.

8. A measuring apparatus in accordance with claim 1, wherein the distance sensor unit is arranged laterally offset with respect to said measuring chamber received in the measuring chamber device.

9. A measuring apparatus in accordance with claim 1, wherein at least two distance sensor units are arranged offset with respect to one another.

10. A method for the determination of a parameter of a medical fluid, comprising the steps of:

leading the fluid through a measuring chamber;

measuring a measured value whose value depends on an extent of the measuring chamber in a measuring direction, said measured value allowing for determination of the parameter, or of a value being in a fixed relationship thereto, with a known value for said extent of the measuring chamber; and

said measurement of the measured value additionally determining a value that is in a fixed relationship with the extent of the measuring chamber in the measuring direction, or a change in said extent.

11. A method in accordance with claim 10, wherein the extent is determined using an electrical and/or magnetic field which is generated by a field generation device at a location of a field sensor, said field generation device and said field sensor being arranged such that a distance therebetween is in a fixed relationship with the extent.

12. A method in accordance with claim 11, wherein a magnetic field is generated by said field generation device having at least a permanent magnet, said field sensor including a magneto-resistive sensor for measuring a strength and/or direction of said magnet.

13. A method in accordance with claim 10, wherein the change in the extent is determined from a change in an electrical and/or magnetic field which results from a change in a distance between a field generation device and a field sensor.

14. A method in accordance with claim 10, wherein the measured value includes a run time of an ultrasonic wave.

15. A method in accordance with claim 10, wherein the medical fluid includes blood and the method is used in haemo-dialysis.

16. A method in accordance with claim 10 wherein the parameter to be determined is density and/or concentration and/or haemocrit value.

17. A method for the calibration of a measuring apparatus having a measuring chamber through which a medical fluid to be measured is guided, at least one measuring element for measuring a measured value whose value depends on an extent of the measuring chamber, and at least one distance sensor unit, comprising the steps of:

a) sending a fluid with a known value of a parameter through the measuring chamber, with the measuring apparatus being suitable for determination of said parameter;

b) determining a measured value by the measuring element whose value depends on the extent of the measuring chamber in a measuring direction;

c) determining the extent of the measuring chamber in the measuring direction from the known parameter value and the measured value or from a value that is in a fixed relationship thereto;

d) measuring a signal of the distance sensor unit;

e) associating the measured signal with the determined value of the extent of the measuring chamber or with the value that is in a fixed relationship thereto;

f) changing the extent of the measuring chamber; and

g) repeating the steps b) to f) at least once for determination of a characteristic curve between the signal of the distance sensor unit and the extent of the measuring chamber, or the value that is in a fixed relationship thereto.

18. A method for the calibration in accordance with claim 17, wherein the parameter is ultrasound velocity, the measuring element includes an ultrasonic transmitter and an ultrasonic receiver and the measured value is an ultrasonic run time.

19. A method for the calibration in accordance with claim 18, wherein saline solution is used as the fluid for calibration.