Cosmetic skin care compositions

• US 6,821,524 B2
• Filed: 06/03/2002
• Issued: 11/23/2004
• Est. Priority Date: 06/03/2002
• Status: Expired due to Term

• Current Assignee: Jan Marini Skin Research Incorporated
• Original Assignee: Jan Marini Skin Research Incorporated
• Inventors: Marini, Jan L.
• Primary Examiner(s): Dodson, Shelley A.
• Application Number:
  US10/161,884
• Publication Number:
  US 20030228266A1
• Time in Patent Office: 904 Days
• Field of Search: 424/59, 424/60, 424/400, 424/401, 514/12
• US Class Current: 424/401
• CPC Class Codes: A61K 8/64 Proteins; Peptides; Derivatives or degradation products thereof
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

Cosmetic skin care compositions containing thymosin beta 4 are provided. The compositions improve the appearance of aged or damaged skin.

Claims

1. A cosmetic composition for topical treatment of skin, comprising from 0.1 ng/ml to 1 μ

g/ml of human thymosin β

4; and

a cosmetically acceptable vehicle.

2. A cosmetic composition for topical treatment of skin, comprising from 0.1 ng/ml to 1 μ

g/ml of human thymosin β

4;

human transforming growth factor β

1 at a concentration from 5 pg to 1 μ

g/ml, and a cosmetically acceptable vehicle.

3. A cosmetic composition for topical treatment of skin, comprising from 0.1 ng/ml to 1 μ

g/ml of human thymosin β

4;

human vascular endothelial growth factor at a concentration from 1 pg/ml to 1 μ

g/ml and a cosmetically acceptable vehicle.

4. The composition according to claim 3, and further comprising one or more of estradiol, progesterone;

pregnanalone;

coenzyme Q10;

methylsolanomethane (MSM);

copper peptide (copper extract);

plankton extract (phytosome);

glycolic acid;

kojic acid;

ascorbyl palmitate;

all trans retinol;

azaleic acid;

salicylic acid;

broparoestrol;

estrone;

adrostenedione; and

androstanediol.

5. The composition according to claim 3, wherein said composition further comprises a sunblock.

6. The composition according to claim 3, wherein said cosmetically acceptable vehicle is an oil in water, or water in oil emulsion.

7. A method for improving the appearance of the skin, the method comprising:

applying topically a cosmetic composition comprising from 0.1 ng/ml to 1 μ

g/ml of human thymosin β

4; and

a cosmetically acceptable vehicle.

8. A method for improving the appearance of the skin, the method comprising:

applying topically a cosmetic composition comprising from 0.1 ng/ml to 1 μ

g/ml of human thymosin β

4, human transforming growth factor β

1 at a concentration from 5 pg to 1 μ

g/ml, and a cosmetically acceptable vehicle.

9. A method for improving the appearance of the skin, the method comprising:

applying topically a cosmetic composition comprising from 0.1 ng/ml to 1 μ

g/ml of human thymosin β

4, human vascular endothelial growth factor at a concentration from 1 pg/ml to 1 μ

g/ml, and a cosmetically acceptable vehicle.

10. The method according to claim 9, wherein said skin is aged, photoaged, dry, lined or wrinkled skin.

11. The method according to claim 10, wherein said composition further comprises one or more of estradiol;

progesterone;

pregnanalone;

coenzyme Q10;

methylsolanomethane (MSM);

copper peptide (copper extract);

plankton extract (phytosome);

glycolic acid;

kojic acid;

ascorbyl palmitate;

all trans retinol;

azaleic acid;

salicylic acid;

broparoestrol;

estrone;

adrostenedione; and

androstanediols.

12. The method according to claim 10, wherein said composition further comprises a sunblock.

13. The method according to claim 10, wherein said cosmetically acceptable vehicle is an oil in water, or water in oil emulsion.