Biomedical devices containing internal wetting agents

• US 6,822,016 B2
• Filed: 09/06/2002
• Issued: 11/23/2004
• Est. Priority Date: 09/10/2001
• Status: Expired due to Term

• Current Assignee: Johnson & Johnson Vision Care Incorporated (Johnson & Johnson)
• Original Assignee: Johnson & Johnson Vision Care Incorporated (Johnson & Johnson)
• Inventors: McCabe, Kevin P., Steffen, Robert B., Vanderlaan, Douglas G., Young, Kent A., Molock, Frank F., Hill, Gregory A., Alli, Azaam
• Primary Examiner(s): Robertson, Jeffrey B.
• Application Number:
  US10/236,538
• Publication Number:
  US 20030162862A1
• Time in Patent Office: 809 Days
• Field of Search: 523/106, 523/107, 524/261, 524/265, 525/474, 528/25, 528/26, 528/28, 528/41, 623/6.11
• US Class Current: 523/107
• CPC Class Codes: A61L 2430/16 for reconstruction of eye parts, e.g. intraocular lens, cornea
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/26 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 27/52 Hydrogels or hydrocolloids
• CPC Class Codes: C08F 251/00 Macromolecular compounds obtained by polymerising monomers on to polysaccharides or derivatives thereof
• CPC Class Codes: C08F 265/04 on to polymers of esters
• CPC Class Codes: C08F 271/00 Macromolecular compounds obtained by polymerising monomers on to polymers of nitrogen-containing monomers as defined in group C08F26/00
• CPC Class Codes: C08F 271/02 on to polymers of monomers containing heterocyclic nitrogen
• CPC Class Codes: C08F 283/06 on to polyethers, polyoxymethylenes or polyacetals C08F283/004 takes precedence
• CPC Class Codes: C08F 283/12 on to polysiloxanes
• CPC Class Codes: C08F 290/06 Polymers provided for in subclass C08G
• CPC Class Codes: C08F 290/068 Polysiloxanes
• CPC Class Codes: C08F 291/00 Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds according to more than one of the groups C08F251/00 - C08F289/00
• CPC Class Codes: C08L 83/04 Polysiloxanes
• CPC Class Codes: G02B 1/043 Contact lenses
• CPC Class Codes: G02C 7/022 Ophthalmic lenses having special refractive features achieved by special materials or material structures G02C7/049 takes precedence

Abstract

This invention includes a wettable biomedical device containing a high molecular weight hydrophilic polymer and a hydroxyl-functionalized silicone-containing monomer.

Claims

1. An ophthalmic device comprising at least one hydroxyl-functionalized silicone-containing monomer and an amount of high molecular weight hydrophilic polymer sufficient to provide said device, without a surface treatment, with an advancing dynamic contact angle of less than about 80°

.

4. The opthalmic device claim 1 wherein said device is a silicone hydrogel contact lens.

5. The ophthalmic device of claim 1 wherein said hydroxyl-functionalized silicone containing monomer is present in a compatibilizing effective mount.

6. The ophthalmic device of claim 1 wherein said hydroxyl-functionalized silicone containing monomer is present in an amount between about 5% to about 90%.

7. The opthalmic device of claim 1 comprising about 1% to about 15% high molecular weight hydrophilic polymer.

8. The opthalmic device of claim 1 further comprising 0 to about 80 weight % at least one additional silicone containing monomer.

9. The opthalmic device of claim 1 further comprising 0 to about 70 weight % at least one hydrophylic monomer.

10. The opthalmic device of claim 1 comprising about 1% to about 15% high molecular weight hydrophilic polymer;

about 5 to about 90 weight % hydroxyl-functionalized silicone containing monomer, 0 to about 80 weight % additional silicone containing monomer and 0 to about 70 weight % hydrophilic monomer.

11. The opthalmic device of claim 1 further comprising a haze value of less than about 100.

12. The opthalmic device of claim 1 further comprising a haze value of less than about 50.

2. An ophthalmic device comprising at least one hydroxyl-functionalized silicone-containing monomer and an amount of high molecular weight hydrophilic polymer sufficient to provide said device, without a surface treatment, with an advancing dynamic contact angle which is at least about 10% lower than an advancing dynamic contact angle for an ophthalmic device which does not contain said hydrophilic polymer.

3. An ophthalmic device comprising at least one hydroxyl-functionalized silicone-containing monomer and an amount of high molecular weight hydrophilic polymer sufficient to provide said device, without a surface treatment, with tear film break up time after about one day of wear of at least about 7 seconds.