Particle separation mechanism

• US 6,822,180 B2
• Filed: 12/06/2001
• Issued: 11/23/2004
• Est. Priority Date: 12/08/2000
• Status: Active Grant

• Current Assignee: Minolta Corporation Limited (Konica Minolta Inc.)
• Original Assignee: Minolta Corporation Limited (Konica Minolta Inc.)
• Inventors: Sando, Yusuhiro, Fujii, Yasuhisa
• Primary Examiner(s): Wang, Donald P.
• Assistant Examiner(s): RODRIGUEZ, JOSEPH C
• Application Number:
  US10/010,665
• Publication Number:
  US 20020108889A1
• Time in Patent Office: 1,083 Days
• Field of Search: 209/39, 209/128, 209/129, 209/130, 209/135, 209/208, 209/214, 209/223.1, 209/232, 209/906, 436/10, 436/520, 436/63, 422/81, 422/100
• US Class Current: 209/128
• CPC Class Codes: B01D 57/02 by electrophoresis treatment of water, waste water, sewage or sludge by electrophoresis C02F1/469; electrophoretic production of compounds or non-metals C25B7/00; investigating or analysing materials by using electrophoresis G01N27/26
• CPC Class Codes: B03C 1/30 Combinations with other devices, not otherwise provided for
• CPC Class Codes: B03C 5/026 using open-gradient differential dielectric separation, i.e. using electrodes of special shapes for non-uniform field creation, e.g. Fluid Integrated Circuit [FIC]
• CPC Class Codes: Y10S 209/906 Pneumatic or liquid stream feeding item
• CPC Class Codes: Y10T 436/117497 with a continuously flowing sample or carrier stream

Abstract

A microchip comprises a flow pass in which a solution containing particles can flow, and a deflection mechanism for deflecting a portion of the particles as the particles flow through the flow pass.

Claims

1. A microchip comprising:

a flow pass for containing a solution having particles therein;

a particle capture unit, including a plurality of projections, disposed on a deflection side of said flow pass for capturing at least a portion of said particles between said plurality of projections; and

a deflection mechanism for deflecting said portion of said particles as said particles flow through said flow pass;

wherein said particle capture unit protrudes into only a portion of a cross section of said flow pass.

2. A microchip according to claim 1, wherein said plurality of projections protrudes from said deflection side of said flow pass in a direction transverse to a direction of flow of said flow pass.

3. A microchip according to claim 1, wherein said plurality of projections protrudes into only a portion of a cross section of said flow pass.

4. A microchip according to claim 1, wherein each of said plurality of projections has a columnar form.

5. A microchip according to claim 1, wherein each of said plurality of projections is a plate.

6. A microchip according to claim 1, wherein said deflection mechanism is adapted to direct said portion of said particles towards said deflection side of said flow pass so as to be captured in said particle capture unit.

7. A microchip according to claim 1, wherein said deflection mechanism is adapted to direct said portion of said particles away from said deflection side of said flow pass.

8. A microchip according to claim 1, wherein said deflection mechanism is adapted to generate a field in a direction transverse to a direction of flow of said flow pass.

9. A microchip according to claim 8, wherein said field is a magnetic field, said portion of said particles being magnetic particles so as to be deflected by said magnetic field.

10. A microchip according to claim 8, wherein said field is an electric field, said portion of said particles being electrically charged so as to be deflected by said electric field.

11. A microchip according to claim 10, wherein said deflection mechanism comprises electrodes for generating said electric field.

12. A microchip according to claim 1, further comprising a micropump for causing said solution to flow through said flow pass.

13. A microchip according to claim 1, further comprising first and second propulsion electrodes, wherein a voltage applied across said first and second propulsion electrodes causes said particles to flow through said flow pass.

14. A method for separating particles from a solution containing said particles, the method comprising the steps of:

causing said particles to flow through a flow pass of a microchip;

forming, in a deflection region of said flow pass, a field in a direction transverse to a direction of flow of said flow pass, said field deflecting a portion of said particles to a deflection surface of said flow pass; and

capturing said portion of said particles between a plurality of projections formed on said deflection surface in said deflection region of said flow pass, said plurality of projections protruding into only a portion of a cross section of said flow pass.

15. A method according to claim 14, further comprising the steps of:

forming, in said deflection region, a field for deflecting said portion of said particles away from said particle capture unit; and

causing said particles to flow through said flow pass, said particles being segregated from said solution and released from said microchip.

16. A method according to claim 14, wherein said plurality of projections protrudes into only a portion of a cross section of said flow pass.

17. A method according to claim 14, wherein said plurality of projections protrudes from said deflection region of said flow pass in said direction transverse to said direction of flow of said flow pass.

18. A method according to claim 14, wherein said step of causing said particles to flow comprises the step of pumping said solution with a micropump.

19. A method according to claim 14, wherein said step of causing said particles to flow comprises the step of applying a voltage across first and second propulsion electrodes disposed on opposing ends of said flow pass.