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Protein and peptide sensors using electrical detection methods

  • US 6,824,669 B1
  • Filed: 02/17/2000
  • Issued: 11/30/2004
  • Est. Priority Date: 02/17/2000
  • Status: Expired due to Term
First Claim
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1. A method of electrically detecting a molecular interaction between an immobilized probe molecule and a protein or peptide target molecule, comprising:

  • (a) detecting a first electrical signal in one or a plurality of microelectrodes in contact with linker moieties to which probe molecules are immobilized, (b) exposing said one or a plurality of microelectrodes to a sample mixture containing a protein or peptide target molecule, (c) detecting a second electrical signal in said one or a plurality of microelectrodes, (d) comparing said first electrical signal with said second electrical signal, (e) determining whether said first electrical signal is different from said second electrical signal, (f) exposing said one or a plurality of microelectrodes to one or a plurality of target binding molecules comprising an electrochemical label, (g) detecting a third electrical signal in said one or a plurality of microelectrodes, and (h) comparing said second electrical signal with said third electrical signal.

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