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Regulation of endogenous gene expression in cells using zinc finger proteins

  • US 6,824,978 B1
  • Filed: 11/03/2000
  • Issued: 11/30/2004
  • Est. Priority Date: 01/12/1999
  • Status: Expired due to Term
First Claim
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1. A method of inhibiting expression of an endogenous cellular gene in a cell, the method comprising the step of:

  • contacting a first target site in the endogenous cellular gene with a first zinc finger protein, wherein said first zinc finger protein is engineered and wherein the Kd of the zinc finger protein is less than about 25 nM;

    thereby inhibiting expression of the endogenous cellular gene.

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