Method for adjusting a blood analyte measurement
First Claim
1. A method of analyzing a material sample, said method comprising:
- placing said material sample in operative engagement with an analyte detection system;
operating said analyte detection system according to an operation algorithm by which said analyte detection system computes a hydration correction coefficient based on changes in electromagnetic energy generated and emitted by at least one of said material sample and a test sample;
determines an estimated concentration of an analyte in said material sample; and
reduces the effect of a hydration level of said material sample on said estimated concentration.
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Accused Products
Abstract
A device and method for determining analyte concentrations within a material sample are provided. A modulating temperature gradient is induced in the sample and resultant, emitted infrared radiation is measured at selected analyte absorbance peaks and reference wavelengths. The modulating temperature gradient is controlled by a surface temperature modulation. A transfer function relating the surface temperature modulation to a modulation of the measured infrared radiation is provided. Phase and magnitude differences in the transfer function are detected. These phase and magnitude differences, having a relationship to analyte concentration, are measured, correlated and processed to determine analyte concentration in the material sample. A method for adjusting an analyte measurement is provided. The method provides a hydration correction process for calibration and correction whereby analyte concentrations within the material sample may be determined. The hydration correction process is particularly suitable for determining blood analyte concentrations within human tissue.
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Citations
11 Claims
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1. A method of analyzing a material sample, said method comprising:
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placing said material sample in operative engagement with an analyte detection system;
operating said analyte detection system according to an operation algorithm by which said analyte detection system computes a hydration correction coefficient based on changes in electromagnetic energy generated and emitted by at least one of said material sample and a test sample;
determines an estimated concentration of an analyte in said material sample; and
reduces the effect of a hydration level of said material sample on said estimated concentration.- View Dependent Claims (2, 3, 4)
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5. A method of analyzing a material sample, said method comprising:
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detecting non-reflected electromagnetic energy generated and emitted by at least one of said material sample and a test sample;
determining a hydration correction coefficient base on aid non-reflected electromagnetic energy;
placing said material sample in operative engagement with a analyte detection system;
determining an estimated concentration of an analyte in said material sample; and
reducing the effect of a hydration level of said material sample on said estimated concentration. - View Dependent Claims (6, 7, 8)
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9. An analyte detection system comprising:
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a detector array;
a processing circuit in communication with said detector array; and
a module executable by said processing circuit whereby said processing circuit computes a hydration correction coefficient based on internal electromagnetic emissions of least one of a material sample and a test sample;
computes an estimated concentration of an analyte in said material sample and reduces the effect of a hydration level of said material sample on said estimated concentration.- View Dependent Claims (10, 11)
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Specification