Compounds having unique CB1 receptor binding selectivity and methods for their production and use
First Claim
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1. A compound of formula (III) wherein R is a linear or branched hydrocarbon group having from 7 to 12 carbons, or N-piperidinyl.
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Abstract
Compounds are provided that are amide analogs of SR141716A having unique CB1 receptor selectivity and providing WIN sparing binding characteristics, pharmaceutical compositions containing the compounds and their use in a method of treatment of CB1 receptor related disorders, such as obesity, schizophrenia, memory dysfunction and marijuana abuse.
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Citations
22 Claims
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1. A compound of formula (III)
wherein R is a linear or branched hydrocarbon group having from 7 to 12 carbons, or N-piperidinyl.
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4. A pharmaceutical composition, comprising:
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an alkyl amide of formula (III) wherein R is a linear or branched hydrocarbon group having from 7 to 12 carbons, or N-piperidinyl, and a pharmaceutically acceptable carrier. - View Dependent Claims (5, 6)
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7. A method for the treatment of obesity, comprising:
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administering to a subject in need thereof, an effective amount of an alkyl amide compound of Formula (III) wherein R is a linear or branched hydrocarbon group having from 7 to 12 carbons, or N-piperidinyl. - View Dependent Claims (8, 9, 10, 11)
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12. A compound:
- of formula (II)
wherein R is a linear or branched hydrocarbon group having from 9 to 12 carbons. - View Dependent Claims (13, 14)
- of formula (II)
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15. A pharmaceutical composition, comprising:
- an alkyl amide of formula (II)
wherein R is a linear or branched hydrocarbon group having from 9 to 12 carbons, and a pharmaceutically acceptable carrier. - View Dependent Claims (16, 17)
- an alkyl amide of formula (II)
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18. A method for the treatment of obesity, comprising:
- administering to a subject in need thereof, an effective amount of an alkyl amide compound of Formula (II) having WIN-sparing properties
wherein R is a linear or branched hydrocarbon group having from 9 to 12 carbons. - View Dependent Claims (19, 20, 21, 22)
- administering to a subject in need thereof, an effective amount of an alkyl amide compound of Formula (II) having WIN-sparing properties
Specification