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Compositions and methods using platinum compounds for nucleic acid labeling

  • US 6,825,330 B2
  • Filed: 03/01/2002
  • Issued: 11/30/2004
  • Est. Priority Date: 03/02/2001
  • Status: Expired due to Fees
First Claim
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1. A composition comprising the formula:

  • embedded imagewherein;

    R1-R5 may be the same or different and are independently selected from the group consisting of H, alkyl (1 to 10 carbon atoms), benzyl, sulfonate, phosphonate, NO2, CF3, halogen, O—

    R6, —

    (C═

    O)OR6, or —

    OCH2(C═

    O)R6 and a salt, wherein R6 is a straight or branched, saturated or unsaturated, substituted or unsubstituted alkyl having 1-10 carbons;

    X1 and X2 may be the same or different and at least one of X1 or X2 is a leaving group; and

    linker is a moiety joining a nitrogen to a detectable marker, D.

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