Antisense modulation of PLML expression
First Claim
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1. An antisense oligonucleotide 8 to 80 nucleobases in length targeted to nucleobases 694 through 799 of a 3′
- -untranslated region of a nucleic acid molecule encoding human PLML (SEQ ID NO;
3), wherein said antisense oligonucleotide specifically hybridizes with said region of said nucleic acid molecule encoding human PLML.
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of PLML. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PLML. Methods of using these compounds for modulation of PLML expression and for treatment of diseases associated with expression of PLML are provided.
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10 Claims
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1. An antisense oligonucleotide 8 to 80 nucleobases in length targeted to nucleobases 694 through 799 of a 3′
- -untranslated region of a nucleic acid molecule encoding human PLML (SEQ ID NO;
3), wherein said antisense oligonucleotide specifically hybridizes with said region of said nucleic acid molecule encoding human PLML. - View Dependent Claims (2, 3, 4, 5, 6, 8, 9, 10)
- -untranslated region of a nucleic acid molecule encoding human PLML (SEQ ID NO;
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7. The antisense oligonucleotide of clai 6 wherein the modified nucleobase is a 5-methylcytosine.
Specification