Gastrointestinal electrical stimulation

• US 6,826,428 B1
• Filed: 03/27/2002
• Issued: 11/30/2004
• Est. Priority Date: 04/11/2000
• Status: Expired due to Term

• Current Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Inventors: Pasricha, Pankaj Jay, Chen, Jiande
• Primary Examiner(s): Jastrzab, Jeffrey R.
• Application Number:
  US09/913,556
• Time in Patent Office: 979 Days
• Field of Search: 607/40, 607/41, 607/138, 607/133
• US Class Current: 607/40
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control

Abstract

The present invention is directed to a method of regulating gastrointestinal action in a subject using a stimulatory electrode and a sensor to provide retrograde feedback control of electrical stimulation to the GI tract. The invention is further directed to a method for reducing weight in a subject, again using a stimulatory electrode and a sensor to provide retrograde feedback control of electrical stimulation to the stomach. The invention is further directed to a method of providing electrical field stimulation to a gastrointestinal organ, as well as a method of providing an electrical potential gradient in a gastrointestinal organ. Further provided is a method of stimulating the vagus nerve of a subject. Additionally provided is a method of placing a device in the gastrointestinal tract or wall of a subject from the exterior of the subject, using a needle to insert the device.

Claims

1. A method of regulating gastrointestinal action in a subject, the method comprising:

determining an optimum level of total gastrointestinal action in a subject, the total gastrointestinal action including naturally occurring gastrointestinal action and non-naturally occurring gastrointestinal action;

positioning a stimulatory electrode relative to the subject so that the stimulatory electrode can generate non-naturally occurring gastrointestinal action;

positioning a sensor relative to the subject so that the sensor senses the level of total gastrointestinal action, the sensor being operatively connected to the stimulatory electrode;

periodically detecting the level of total gastrointestinal action with the sensor; and

periodically generating non-naturally occurring gastrointestinal action with the stimulatory electrode when the detected level of total gastrointestinal action differs from the optimum level until the detected level of total gastrointestinal action substantially equals the optimum level.

2. The method of claim 1 wherein the gastrointestinal action is gastrointestinal electrical activity.

3. The method of claim 1 wherein the gastrointestinal action is gastrointestinal contractile activity.

4. The method of claim 3 wherein the contractile activity is stomach contractile activity.

5. The method of claim 1 wherein the gastrointestinal action is gastrointestinal motility.

6. The method of claim 1 wherein the gastrointestinal action is gastric emptying.

7. The method of claim 1 wherein the gastrointestinal action is gastrointestinal pressure.

8. The method of claim 1 wherein the gastrointestinal action is vagal activity.

9. The method of claim 1 wherein the gastrointestinal action is gastrointestinal impedence.

10. The method of claim 1 wherein the gastrointestinal action is afferent nerve activity.

11. A method for reducing weight in a subject having a stomach, the method comprising:

determining an optimum level of total stomach electrical activity in a subject which reduces weight in the subject, the total stomach electrical activity including naturally occurring stomach electrical activity and non-naturally occurring stomach electrical activity;

positioning a stimulatory electrode relative to the subject so that the stimulatory electrode can generate non-naturally occurring stomach electrical activity;

positioning an electrical activity sensor relative to the subject so that the electrical activity sensor senses the level of total stomach electrical activity, the electrical activity sensor being operatively connected to the stimulatory electrode;

periodically detecting the level of total stomach electrical activity with the electrical activity sensor; and

periodically generating non-naturally occurring stomach electrical activity with the stimulatory electrode when the detected level of total stomach electrical activity differs from the optimum level until the detected level of total stomach electrical activity substantially equals the optimum level.