Shunt device and method for treating glaucoma

• US 6,827,699 B2
• Filed: 05/27/2003
• Issued: 12/07/2004
• Est. Priority Date: 04/26/1999
• Status: Expired due to Term

• Current Assignee: Glaukos Corporation
• Original Assignee: GMP Vision Solutions, Inc.
• Inventors: Brown, Reay H., Lynch, Mary G.
• Primary Examiner(s): Look, Edward K.
• Assistant Examiner(s): Edgar, Richard A.
• Application Number:
  US10/445,411
• Publication Number:
  US 20030220602A1
• Time in Patent Office: 560 Days
• Field of Search: 604/8, 604/264, 604/284, 604/523, 606/107, 623/4.1, 623/1.1, 623/11.11, 623/1.35
• US Class Current: 604/8
• CPC Class Codes: A61F 2230/0008 elliptical or oval
• CPC Class Codes: A61F 2230/0052 T-shaped
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: A61M 2210/0612 Eyes
• CPC Class Codes: A61M 25/0068 Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
• CPC Class Codes: A61M 25/007 Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
• CPC Class Codes: A61M 25/0074 Dynamic characteristics of the catheter tip, e.g. openable, closable, expandable or deformable

Abstract

Shunt devices and a method for continuously decompressing elevated intraocular pressure in eyes affected by glaucoma by diverting excess aqueous humor from the anterior chamber of the eye into Schlemm'"'"'s canal where post-operative patency can be maintained with an indwelling shunt device which surgically connects the canal with the anterior chamber. The shunt devices provide uni- or bi-directional flow of aqueous humor into Schlemm'"'"'s canal.

Claims

1. A method of controlling the flow of aqueous humor in a living eye having an anterior chamber, a Schlemm'"'"'s canal, and an episcleral venous system, the method comprising:

introducing into the living eye an indwelling tubular body which leads from the anterior chamber into Schlemm'"'"'s canal to provide an aqueous humor directing channel out of the anterior chamber;

conforming an inner wall of Schlemm'"'"'s canal to the shape of the tubular body; and

draining aqueous humor through the tubular body to reduce intraocular pressure in the living eye.

2. The method of claim 1, wherein the inner wall of Schlemm'"'"'s canal conforms to an inner diameter of between approximately 0.1 mm and 0.5 mm.

3. The method of claim 1, wherein the inner wall of Schlemm'"'"'s canal conforms to a radius of curvature of 6 mm.

4. The method of claim 1, wherein aqueous humor is drained at a sufficient flow rate to reduce build-up of aqueous humor in the anterior chamber without hypotony, and wherein the flow rate is below about 2.5 microliters per minute.

5. A method of controlling the flow of aqueous humor in a living eye having an anterior chamber, a Schlemm'"'"'s canal, and an episcleral venous system, the method comprising:

introducing into the living eye an indwelling tubular body which leads from the anterior chamber into Schlemm'"'"'s canal to provide an aqueous humor directing channel out of the anterior chamber;

anchoring the tubular body to reduce expulsion thereof from Schlemm'"'"'s canal; and

draining aqueous humor through the tubular body to reduce intraocular pressure in the living eye.

6. A method of controlling the flow of aqueous humor in a living eye having an anterior chamber, a Schlemm'"'"'s canal, and an episcleral venous system, the method comprising:

introducing into the living eye an indwelling tubular body which leads from the anterior chamber into Schlemm'"'"'s canal to provide an aqueous humor directing channel out of the anterior chamber;

anchoring the tubular body to reduce expulsion thereof from the anterior chamber; and

draining aqueous humor through the tubular body to reduce intraocular pressure in the living eye.

7. A method of controlling the flow of aqueous humor in a living eye having an anterior chamber, a Schlemm'"'"'s canal, and an episcleral venous system, the method comprising:

introducing into the living eye an indwelling tubular body which leads from the anterior chamber into Schlemm'"'"'s canal to provide an aqueous humor directing channel out of the anterior chamber;

stabilizing the tubular body in the eye with an anchor portion of the tubular body;

and

draining aqueous humor through the tubular body to reduce intraocular pressure in the living eye.

8. A method of controlling the flow of aqueous humor in a living eye having an anterior chamber, a Schlemm'"'"'s canal, and an episcleral venous system, the method comprising:

introducing into the living eye an indwelling tubular body which leads from the anterior chamber into Schlemm'"'"'s canal to provide an aqueous humor directing channel out of the anterior chamber; and

draining aqueous humor through the tubular body to reduce intraocular pressure in the living eye, wherein the tubular body comprises a therapeutic agent.

9. A method of controlling the flow of aqueous humor in a living eye having an anterior chamber, a Schlemm'"'"'s canal, and an episcleral venous system, the method comprising:

introducing into the living eye an indwelling tubular body which leads from the anterior chamber into Schlemm'"'"'s canal to provide an aqueous humor directing channel out of the anterior chamber; and

draining aqueous humor through the tubular body to reduce intraocular pressure in the living eye, wherein the tubular body is dimensioned to allow non-linear fluid communication, and wherein the tubular body comprises a T-shape.

10. A method of controlling the flow of aqueous humor in a living eye having an anterior chamber, a Schlemm'"'"'s canal, and an episcleral venous system, the method comprising:

introducing into the living eye an indwelling tubular body which leads from the anterior chamber into Schlemm'"'"'s canal to provide an aqueous humor directing channel out of the anterior chamber; and

draining aqueous humor through the tubular body to reduce intraocular pressure in the living eye, wherein the tubular body is dimensioned to allow non-linear fluid communication, and wherein the tubular body comprises a V-shape.

11. A method of controlling the flow of aqueous humor in a living eye having an anterior chamber, a Schlemm'"'"'s canal, and an episcleral venous system, the method comprising:

introducing a tubular body between Schlemm'"'"'s canal and the anterior chamber, wherein the tubular body provides a first aqueous humor directing channel from the anterior chamber toward Schlemm'"'"'s canal;

anchoring the tubular body; and

draining aqueous humor through the tubular body to reduce build-up of aqueous humor in the living eye.

12. The method of claim 11, wherein the anchoring reduces expulsion of the device from Schlemm'"'"'s canal.

13. The method of claim 11, wherein the anchoring reduces expulsion of the device from the anterior chamber.

14. A method of controlling the flow of aqueous humor in a living eye having an anterior chamber, a Schlemm'"'"'s canal, and an episcleral venous system, the method comprising:

placing a substantially hollow device in the living eye leading from Schlemm'"'"'s canal to the anterior chamber of the eye, wherein device provides an elongated aqueous humor directing channel within Schlemm'"'"'s canal to guide the flow of aqueous humor from the anterior chamber toward the episcleral venous system, wherein the outer diameter of the portion of the device placed within Schlemm'"'"'s canal is between about 0.1 mm and 0.5 mm;

conforming an inner wall of Schlemm'"'"'s canal to an inner diameter of between approximately 0.1 mm and 0.5 mm; and

draining aqueous humor alone the elongated aqueous humor directing channel to maintain pressure above approximately 6.0 mmHg in the living eye.

15. A method of controlling the flow of aqueous humor in a living eye having an anterior chamber, a Schlemm'"'"'s canal, and an episcleral venous system, the method comprising:

providing a tubular body in Schlemm'"'"'s canal comprising an elongated aqueous humor directing channel, wherein the outer diameter of the tubular body in Schlemm'"'"'s canal is between about 0.1 mm and 0.5 mm, and the aqueous humor directing channel guides the flow of aqueous humor from the anterior chamber toward the episcleral venous system; and

draining aqueous humor along the elongated aqueous humor directing channel at a sufficient flow rate to maintain pressure above approximately 6.0 mmHg in the living eye, wherein the tubular body comprises a therapeutic agent.

16. A method of controlling the flow of aqueous humor in a living eye having an anterior chamber, a Schlemm'"'"'s canal, and an episcleral venous system, the method comprising:

providing a tubular body in Schlemm'"'"'s canal comprising an elongated aqueous humor directing channel, wherein the outer diameter of the tubular body in Schlemm'"'"'s canal is between about 0.1 mm and 0.5 mm, and the aqueous humor directing channel guides the flow of aqueous humor from the anterior chamber toward the episcleral venous system; and

draining aqueous humor along the elongated aqueous humor directing channel at a sufficient flow rate to maintain pressure above approximately 6.0 mmHg in the living eye, wherein the tubular body further comprises a T-shape.

17. A method of controlling the flow of aqueous humor in a living eye having an anterior chamber, a Schlemm'"'"'s canal, and an episcleral venous system, the method comprising:

providing a tubular body in Schlemm'"'"'s canal comprising an elongated aqueous humor directing channel, wherein the outer diameter of the tubular body in Schlemm'"'"'s canal is between about 0.1 mm and 0.5 mm, and the aqueous humor directing channel guides the flow of aqueous humor from the anterior chamber toward the episcleral venous system; and

draining aqueous humor along the elongated aqueous humor directing channel at a sufficient flow rate to maintain pressure above approximately 6.0 mmHg in the living eye, wherein the tubular body further comprises a V-shape.

18. A method of controlling the flow of aqueous humor in a living eye having an anterior chamber, a Schlemm'"'"'s canal, and an episcleral venous system, the method comprising:

providing a tubular body in Schlemm'"'"'s canal comprising an elongated aqueous humor directing channel, wherein the outer diameter of the tubular body in Schlemm'"'"'s canal is between about 0.1 mm and 0.5 mm, and the aqueous humor directing channel guides the flow of aqueous humor from the anterior chamber toward the episcleral venous system; and

draining aqueous humor along the elongated aqueous humor directing channel at a sufficient flow rate to maintain pressure above approximately 6.0 mmHg in the living eye, wherein the tubular body further comprises first and second portions that meet at a junction, the first and second portions being oriented transverse to each other.

19. The method of claim 18, wherein the first portion has a first length defined from the junction to a first open end and the second portion has a second length defined between second and third open ends, with the first length being different from the second length.