Method of identifying and treating a pathologic region of an intervertebral disc

• US 6,827,716 B2
• Filed: 09/30/2002
• Issued: 12/07/2004
• Est. Priority Date: 09/30/2002
• Status: Active Grant

• Current Assignee: Depuy Acromed
• Original Assignee: Depuy Spine Incorporated (Johnson & Johnson)
• Inventors: Serhan, Hassan, Reynolds, Martin A., Ryan, Thomas P.
• Primary Examiner(s): PEFFLEY, MICHAEL F
• Application Number:
  US10/261,215
• Publication Number:
  US 20040064023A1
• Time in Patent Office: 799 Days
• Field of Search: 606/27-31, 606/41, 606/48-50, 607/99, 607/101, 607/102, 607/116, 607/117
• US Class Current: 606/41
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 2017/00057 Light
• CPC Class Codes: A61B 2017/00261 Discectomy
• CPC Class Codes: A61B 2018/0044 Spinal cord
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00

Abstract

This invention relates to a method of treating an intervertebral disc comprising locally identifying a pathologic tissue site and therapeutically treating the identified site.

Claims

1. A method of therapeutically treating an intervertebral disc having a pathologic region, the method comprising the steps of:

a) positioning a probe having a diagnostic element adjacent to the disc,

b) activating the diagnostic element to identify the pathologic region as the probe is adjacent the disc, and

c) therapeutically treating the identified pathologic region.

2. The method of claim 1 wherein the treatment comprises coagulating a collagen component of an annulus fibrosus portion of the disc.

3. The method of claim 1 wherein the treatment comprises denervating a nociceptor contained within an annulus fibrosus portion of the disc.

4. The method of claim 1 wherein the probe is positioned via a percutaneously placed needle.

5. The method of claim 1 wherein the probe further comprises a therapeutic element, and the therapeutic element carries out the treatment step.

6. The method of claim 5 wherein the diagnostic element comprises an optical sensor and the therapeutic element comprises an ultrasound transducer.

7. The method of claim 1 wherein the pathologic region is on an outside surface of the disc, and the treatment treats at least the outside surface of the disc.

8. The method of claim 7 wherein the therapeutic treatment produces disc shrinkage at a point of disc herniation.

9. The method of claim 7 wherein the pathologic region comprises adhesions located on an outside posterior portion of the disc where a spinal cord outer membrane adheres to an annulus fibrosus.

10. The method of claim 7 further comprising the steps of:

d) identifying a location of a structure of an adjacent vertebral body, and

e) therapeutically treating the identified structure.

11. The method of claim 1 wherein the probe further comprises a therapeutic element and the therapeutic element treats an inner wall of the annulus fibrosus.

12. The method of claim 1 wherein the probe further comprises a therapeutic element, the diagnostic element is an optical element, and the therapeutic element delivers energy via an active electrode.

13. The method of claim 1 wherein the probe further comprises a therapeutic element.

14. The method of claim 1 wherein the diagnostic element is adapted to utilize an analytical technique selected from the group consisting of Raman spectroscopy, fluorescence, autofluorescence, reflected light, impedence, MRI and ultrasound as a means for identifying or analyzing the pathologic region.

15. The method of claim 14 wherein the probe comprises at least two different diagnostic elements.

16. The method of claim 15 wherein the two different diagnostic elements are adapted to respectively utilize the analytic techniques of reflected light and autofluoroscence.

17. The method of claim 1 wherein the probe further comprises a therapeutic element selected from the group consisting of:

i) an element capable of delivering energy to tissue in a therapeutic amount,

ii) an element capable of delivering or removing a material from a location adjacent the element'"'"'s location in the probe;

iii) a mechanical grasping tool for removing or depositing a solid; and

iv) a guidance tool for allowing passage of other devices.

18. The method of claim 17 wherein the therapeutic element is an energy delivery element.

19. The method of claim 18 wherein the energy delivery element is selected from the group consisting of a laser, a ultrasound element comprising an ultrasound transducer, a microwave element, and an RF energy element.

20. The method of claim 18 wherein the therapeutic element is an RF energy element comprising an active electrode and a return electrode.

21. The method of claim 20 wherein the active and return electrodes are disposed on the same probe.

22. The method of claim 1 wherein the step of activating the diagnostic element to identify the pathologic region comprises the substep of performing analysis of information received from a passive sensor by comparing the information against a comparable tissue property information in a computer data base.

23. A method of therapeutically treating an intervertebral disc having a pathologic region, the method comprising the steps of:

a) navigating a probe having a diagnostic element and a therapeutic element to a first position adjacent to the disc,

b) activating the diagnostic element to identify the pathologic region within the disc as the probe is adjacent the disc,

c) navigating the probe to a second position closer to the pathologic region identified in step b), and

d) activating the therapeutic element to treat the pathologic region.

24. The method of claim 23 further comprising the step of:

d) activating the diagnostic element to confirm the therapeutic treatment of the pathologic tissue.

25. A method of therapeutically treating an intervertebral disc having a pathologic region, the method comprising the steps of:

a) positioning a probe having a diagnostic element and a therapeutic element adjacent to the disc, the diagnostic element comprising a sensor and an active element,

b) transmitting energy through the active element to target tissue to produce a signal from the pathologic region as the probe is adjacent the disc,

c) transmitting the signal through the sensor,

d) evaluating the signal to identify the pathologic region, and

e) therapeutically treating the identified pathologic region.

26. The method of claim 25 wherein the therapeutic element of the probe performs step e).