Continuous form microstructure assay array
First Claim
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1. A continuous form microstructure array for conducting a plurality of assays, the microstructure array comprising:
- a flexible elongate laminate having a plurality of microstructures arranged therein, the flexible elongate laminate comprising a first lamina having a first surface, a second lamina having a second surface, and a flexible circuit laminate adjacent to the first lamina, wherein at least one of the first or second lamina has a plurality of openings so that whenever the first surface of the first lamina apposes the second surface of the second lamina each opening of the plurality of openings is in fluid communication with one of said plurality of microstructures, and wherein the flexible circuit laminate comprises a plurality of electrodes, each electrode being in contact with an electroflow medium whenever the electroflow medium is supplied to said microstructures, each of said microstructures comprising;
a sample supply reservoir at an opening;
a sample drain reservoir connected to the sample supply reservoir by one or more microchannel segments;
an elution buffer reservoir;
an analyte waste reservoir; and
a separation channel connecting the elution buffer reservoir and the analyte waste reservoir and intersecting and being in fluid communication with said one or more microchannel segments; and
wherein the flexible elongate laminate forms a roll or or an accordion-folded stack.
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Abstract
A continuous form microstructure array device is constructed as a flexible elongate film laminate containing a plurality of microstructures or arrays of microstructures arranged serially lengthwise along the laminate. The laminate can be continuously drawn from a supply roll or stack, advanced within an analytic device and, when analysis is complete, taken up in a storage roll or stack. The device provides for high throughput microfluidic processing.
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Citations
4 Claims
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1. A continuous form microstructure array for conducting a plurality of assays, the microstructure array comprising:
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a flexible elongate laminate having a plurality of microstructures arranged therein, the flexible elongate laminate comprising a first lamina having a first surface, a second lamina having a second surface, and a flexible circuit laminate adjacent to the first lamina, wherein at least one of the first or second lamina has a plurality of openings so that whenever the first surface of the first lamina apposes the second surface of the second lamina each opening of the plurality of openings is in fluid communication with one of said plurality of microstructures, and wherein the flexible circuit laminate comprises a plurality of electrodes, each electrode being in contact with an electroflow medium whenever the electroflow medium is supplied to said microstructures, each of said microstructures comprising;
a sample supply reservoir at an opening;
a sample drain reservoir connected to the sample supply reservoir by one or more microchannel segments;
an elution buffer reservoir;
an analyte waste reservoir; and
a separation channel connecting the elution buffer reservoir and the analyte waste reservoir and intersecting and being in fluid communication with said one or more microchannel segments; and
wherein the flexible elongate laminate forms a roll or or an accordion-folded stack. - View Dependent Claims (2, 3)
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4. A continuous form microstructure array for detecting one or more analytes produced in a plurality of assays, the microstructure array comprising:
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a flexible elongate laminate forming a roll or or an accordion-folded stack, the flexible elongate laminate having an array of microchannel structures arranged therein, the flexible elongate laminate comprising a first lamina having a first surface and a second lamina having a second surface, wherein at least one of the first or second lamina has a plurality of openings so that whenever the first surface of the first lamina apposes the second surface of the second lamina each opening of the plurality of openings is in fluid communication with one of said plurality of microchannel structures, each of said microchannel structures comprising;
a sample supply reservoir at an opening;
a sample drain reservoir connected to the sample supply reservoir by one or more microchannel segments;
an elution buffer reservoir;
an analyte waste reservoir;
a separation channel connecting the elution buffer reservoir and the analyte waste reservoir and intersecting and being in fluid communication with said one or more microchannel segments; and
a plurality of electrodes connected to conductive traces to generate an electric field between the sample supply reservoir and the sample drain reservoir when an electroflow medium is present in the one or more microchannel segments and to generate an electrical field between the elution buffer revervoir and the analyte waste reservoir when an electroflow medium is present in the separation channel.
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Specification