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Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same

  • US 6,828,305 B2
  • Filed: 06/04/2001
  • Issued: 12/07/2004
  • Est. Priority Date: 06/04/2001
  • Status: Expired due to Fees
First Claim
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1. A mixture of conjugates each comprising a human growth hormone drug coupled to an oligomer that comprises a polyalkylene glycol moiety and a lipophilic moiety that comprises one or more linear, saturated or unsaturated alkyl moieties having 1 to 28 carbon atoms, said mixture having a molecular weight distribution with a standard deviation of less than about 22 Daltons.

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