Blood component measurement apparatus

• US 6,829,496 B2
• Filed: 11/19/2002
• Issued: 12/07/2004
• Est. Priority Date: 11/20/2001
• Status: Active Grant

• Current Assignee: Minolta Corporation Limited (Konica Minolta Inc.)
• Original Assignee: Minolta Corporation Limited (Konica Minolta Inc.)
• Inventors: Ukai, Akihiro, Yamamoto, Shinji, Nagai, Yoshiroh
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US10/298,949
• Publication Number:
  US 20030114737A1
• Time in Patent Office: 749 Days
• Field of Search: 600/310, 600/322, 600/323, 600/330, 600/336
• US Class Current: 600/322
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes

Abstract

In a pulse oximeter (blood component measurement apparatus), a subject body is irradiated periodically with red light and infrared light. Then, carried out sequentially in a time sharing manner are the measurement of the transmitted light intensity through the subject body, the measurement of the pulse wave component of the transmitted light intensity, and the measurement of the dark level in the state that the subject body is not irradiated with the light. On the basis of these measurement values, oxygen saturation of the arterial blood is measured. In the present embodiments, each measurement is carried out with a time interval equal to the period corresponding to the line frequency. In this approach, periodic noise of the line frequency or other noise are eliminated in dark level correction. This permits precise measurement of the blood component.

Claims

1. A blood component measurement apparatus for measuring a blood component in the arterial blood of a subject body comprising:

an illuminating device for illuminating said subject body with predetermined light periodically at first timings;

a light intensity detector for detecting light intensity measurement values of light transmitted through said subject body;

a dark level detector for detecting dark level measurement values periodically at second timings without illumination from said illuminating device;

a pulse wave detector for extracting a pulse wave component from said light intensity measurement values, and thereby detecting pulse wave measurement values; and

a blood component measurer for measuring the blood component of said arterial blood on the basis of said light intensity measurement values, said dark level measurement values, and said pulse wave measurement values;

wherein each time interval between said first timings and said second timings is an integer multiple of the period corresponding to a line frequency.

2. The blood component measurement apparatus according to claim 1, further comprising an actuator for executing a plurality of measurement operations each shifted by a predetermined phase difference of the line frequency, in the measurement in which said first timings and said second timings are repeated alternately.

3. The blood component measurement apparatus according to claim 2, further comprising a first corrector for correcting said light intensity measurement values detected at said first timings, and a second corrector for correcting said pulse wave measurement values, on the basis of said dark level measurement values detected at said second timings each shifted from each of said first timings by the integer multiple of the period corresponding to the line frequency.

4. The blood component measurement apparatus according to claim 3, further comprises a processor for applying a digital filtering process onto a time difference values of said dark-level corrected light intensity measurement values and said dark-level corrected pulse wave measurement values.

5. The blood component measurement apparatus according to claim 2, further comprising a first corrector for correcting said light intensity measurement values detected at said first timings, and a second corrector for correcting said pulse wave measurement values, on the basis of said dark level measurement values detected at said second timings each in the vicinity of each of said first timings.

6. The blood component measurement apparatus according to claim 2, wherein each of said plurality of measurement operations is the combination of:

the measurement of light intensity measurement values;

the measurement of dark level measurement values used for the correction of said light intensity measurement values;

the measurement of pulse wave measurement values; and

the measurement of dark level measurement values used for the correction of said pulse wave measurement values.

7. The blood component measurement apparatus according to claim 2, wherein said predetermined phase difference in said plurality of measurement operations is a time difference generated by dividing an integer multiple of the period corresponding to the line frequency by the number of said plurality of measurement operations.

8. The blood component measurement apparatus according to claim 1, further comprising a calculator for calculating a time difference value of two pulse wave measurement values detected with a time interval equal to the integer multiple of the period corresponding to the line frequency, wherein said blood component measurer measures said blood component also on the basis of said time difference value.

9. The blood component measurement apparatus according to claim 1, wherein said illuminating device illuminates said subject body alternately with two kinds of light having wavelengths different from each other.

10. The blood component measurement apparatus according to claim 9, wherein said illuminating device illuminates a red light and an infrared light.

11. The blood component measurement apparatus according to claim 9, further comprising:

a first generator for correcting said light intensity measurement values on the basis of said dark level measurement values, and thereby generating corrected light intensity measurement values;

a second generator for correcting said pulse wave measurement values on the basis of said dark level measurement values, and thereby generating corrected pulse wave measurement values;

an interpolator for interpolating one of said corrected light intensity measurement values and one of said corrected pulse wave measurement values detected by illuminating with said two kinds of light having different wavelengths at timings different from each other, using said corrected measurement values before and after the timing of illumination; and

a calculator for calculating a simulated value of said corrected light intensity measurement value and a simulated value of said corrected pulse wave measurement value which are simulated as if measured at the same timing when said two kinds of light having different wavelengths illuminate simultaneously, on the basis of the interpolation carried out in said interpolator.

12. The blood component measurement apparatus according to claim 9, wherein said light intensity detector detects said light intensity measurement values amplified by using a first gain, and when said illuminating device does not illuminate said subject body, said dark level detector detects said dark level measurement values amplified by using a second gain equal to said first gain.

13. The blood component measurement apparatus according to claim 9, wherein said pulse wave detector detects said pulse wave measurement values amplified by using a first gain, and when said illuminating device does not illuminate said subject body, said dark level detector detects said dark level measurement values amplified by using a second gain equal to said first gain.

14. A method of measuring a blood component in the arterial blood of a subject body, comprising the steps of:

illuminating said subject body with predetermined light periodically at first timings by an illuminating device;

detecting light intensity measurement values of light transmitted through said subject body;

extracting a pulse wave component from said light intensity measurement values, and thereby detecting pulse wave measurement values;

detecting dark level measurement values periodically at second timings without illumination from said illuminating device; and

measuring the blood component of said arterial blood on the basis of said light intensity measurement values, said dark level measurement values, and said pulse wave measurement values;

wherein each time interval between said first timings and said second timings is an integer multiple of the period corresponding to a line frequency.