Metered dose inhaler

• US 6,830,046 B2
• Filed: 04/29/2002
• Issued: 12/14/2004
• Est. Priority Date: 04/29/2002
• Status: Expired due to Term

• Current Assignee: Hewlett-Packard Development Company, L.P. (HP Inc.)
• Original Assignee: Hewlett-Packard Development Company, L.P. (HP Inc.)
• Inventors: Beeton, Daniel, Blakley, Daniel Robert
• Primary Examiner(s): Lewis, Aaron J.
• Application Number:
  US10/136,005
• Publication Number:
  US 20030200964A1
• Time in Patent Office: 960 Days
• Field of Search: 128/200.14, 128/200.16, 128/202.22, 128/204.21, 128/205.23, 128/203.12
• US Class Current: 128/200.14
• CPC Class Codes: A61M 15/0065 Inhalators with dosage or measuring devices A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52
• CPC Class Codes: A61M 15/0066 with means for varying the dose size
• CPC Class Codes: A61M 15/008 Electronic counters
• CPC Class Codes: A61M 15/025 Bubble jet droplet ejection devices

Abstract

The present invention provides a metered dose inhaler including an ejection mechanism with at least one chamber for containing a medicament. The ejection mechanism is configured to effect controlled ejection of the medicament from the chamber. The inhaler further includes a controller configured to send electronic signals to the ejection mechanism to direct ejection of medicament from such chamber, and configured to selectively alter dosage of the medicament by selected changes in such electronic signal.

Claims

1. A metered dose inhaler comprising:

an ejection mechanism including a plurality of vaporization chambers configured to contain a medicament, the ejection mechanism being configured to selectively effect controlled ejection of medicament from the plurality of vaporization chambers; and

a controller configured to selectively send electronic signals to the ejection mechanism to direct ejection of medicament from a plurality of vaporization chambers, such electronic signals being selectively alterable to effect change in medicament dosage.

2. The metered dose inhaler of claim 1, which further comprises an input in communication with the controller to identify a dosage of medicament ejected by the ejection mechanism.

3. The metered dose inhaler of claim 1, wherein the controller is further configured to receive a nominal dosage and one or more dosage change parameters.

4. The metered dose inhaler of claim 3, wherein the dosage change parameters are set by a manufacturer of the medicament.

5. The metered dose inhaler of claim 3, wherein the dosage change parameters are set by a prescribing physician.

6. The metered dose inhaler of claim 3, wherein the one or more dosage change parameters includes a permissible dosage, and wherein the controller is further configured to restrict dosage change to such permissible dosage.

7. The metered dose inhaler of claim 3, wherein the one or more dosage change parameters includes a loading dosage, and wherein the controller is further configured to direct ejection of the loading dosage of medicament in a first dosing event followed by ejection of the nominal dosage of medicament in a second dosing event.

8. The metered dose inhaler of claim 3, wherein the one or more dosage change parameters includes a dosing ramp, and wherein the controller is further configured to direct ejection of progressive dosages of medicament along such dosing ramp in successive dosing events.

9. The metered dose inhaler of claim 8, wherein the dosing ramp is based on medicament half-life.

10. The metered dose inhaler of claim 8, wherein the dosing ramp is based on patient dosing behavior.

11. The metered dose inhaler of claim 8, wherein the dosing ramp is a look-up table of dosages to be administered.

12. The metered dose inhaler of claim 8, wherein the progressive dosages of medicament along such dosing ramp are increasing dosages.

13. The metered dose inhaler of claim 8, wherein the dosing ramp is linear.

14. The metered dose inhaler of claim 1, wherein the controller is further configured, and to set a frequency of the electronic signals in accordance with such prescribed dosage.

15. The metered dose inhaler of claim 1, wherein the controller is further configured, and to select a size of a subset of vaporization elements receiving the electronic signals in accordance with such prescribed dosage.

16. A metered dose inhaler adapted to release a selectable quantity of an inhalant into a body of a user, the metered dose inhaler comprising:

a storage chamber containing an inhalant;

a plurality of ejection chambers, each in respective fluid communication with the storage chamber to accommodate charging of such ejection chambers with inhalant from the storage chamber, each ejection chamber further including at least one ejection element configured to selectively eject a charge of inhalant from within the ejection chamber upon receipt of an ejection signal; and

a controller adapted to receive a dosage directive, and to transmit ejection signals to the ejection elements to effect release of a prescribed dosage of inhalant via independently controlled ejection of charges of inhalant from such plurality of ejection chambers in a dosing event.

17. The metered dose inhaler of claim 16, wherein the controller is further adapted to receive one or more dosage change parameters.

18. The metered dose inhaler of claim 17, wherein the dosage change parameters are set by a manufacturer of the inhalant.

19. The metered dose inhaler of claim 17, wherein the dosage change parameters are set by a prescribing physician.

20. The metered dose inhaler of claim 17, wherein the one or more dosage change parameters includes a permissible dosage, and wherein the controller is further configured to restrict dosage change to such permissible dosage.

21. The metered dose inhaler of claim 17, wherein the one or more dosage change parameters includes a loading dosage, and wherein the controller is further adapted to direct release of the loading dosage of inhalant in a first dosing event followed by release of the prescribed dosage of inhalant in a second dosing event.

22. The metered dose inhaler of claim 17, wherein the one or more dosage change parameters includes a dosing ramp, and wherein the controller is further configured to direct release of progressive dosages of inhalant along such dosing ramp in successive dosing events.

23. The metered dose inhaler of claim 22, wherein the dosing ramp is based on inhalant half-life.

24. The metered dose inhaler of claim 22, wherein the dosing ramp is based on patient dosing behavior.

25. The metered dose inhaler of claim 22, wherein the dosing ramp is a look-up table of dosages to be administered.

26. The metered dose inhaler of claim 16, further comprising a user input in communication with the controller, the user input being configured to facilitate communication between the user and the controller.

27. The metered dose inhaler of claim 26, wherein the user input is configured to communicate a firing directive from the user to the controller to initiate a dosing event.

28. The metered dose inhaler of claim 26, which further comprises a display configured to communicate information to the user.

29. A method of administering a medicament to a patient comprising:

providing a dose directive indicative of a dosage of medicament to a controller

charging a plurality of vaporization chambers with a charge of medicament so as to expose medicament to a plurality of vaporization elements contained within the plurality of vaporization chambers;

selectively transmitting electronic signals to a plurality of vaporization elements in accordance with the received dosing directive; and

upon receipt of the electronic signals, activating the vaporization elements so as to discharge vaporized droplets of medicament from the associated vaporization chambers to produce the dosage of medicament indicated by the dosing directive.

30. The method of claim 29, which further comprises setting dosage change parameters in accordance with manufacturer directives.

31. The method of claim 29, which further comprises setting dosage change parameters in accordance with physician directives.

32. The method of claim 29, which further comprises changing dosage, in successive dosing events, according to a look-up table of successive dosages to be administered.

33. The method of claim 29, which further comprises changing dosage, in successive dosing events, according to a dosing ramp.

34. The method of claim 29, which further comprises changing dosage, in successive dosing events, where dosing ramp is based on medicament half-life.

35. The method of claim 29, which further comprises changing dosage, in successive dosing events, where dosing ramp is based on patient dosing behavior.

36. The method of claim 29, which further comprises altering a frequency of the electronic signals so as to alter the dosage of medicament produced during a dosing event, including multiple different dosages that change according to a pre-programmed schedule.

37. The method of administering a medicament to a patient comprising:

entering prescription information;

entering security check information;

verifying compatibility of the prescription information with the security check information.

providing a dosing directive indicative of a medicament;

charging at least one vaporization chamber with a charge of medicament so as to expose medicament to one or more vaporization elements contained within the at least one vaporization chamber;

selectively transmitting electronic signals to the one or more vaporization elements in accordance with the received dosing directive; and

upon receipt of the electronic signals, activating the vaporization elements so as to discharge vaporized droplets of medicament from the associated vaporization chambers to produce the dosage of medicament indicated by the dosing directive.

38. The method of claim 37, wherein entering prescription information includes direct entry of one or more of a patient identification, a physician identification, and a medicament identification.

39. The method of claim 38, wherein entering security check information includes indirect entry of one or more of a patient identification, a physician identification, and a medicament identification.

40. A method of administering a medicament to a patient comprising:

providing a dosing directive indicative of a dosage of medicament;

charging at least one vaporization chamber with a charge of medicament so as to expose medicament to one or more vaporization elements contained within the at least one vaporization chamber;

selectively transmitting electronic signals to the one or more vaporization elements in accordance with the received dosing directive; and

upon receipt of the electronic signals, activating the vaporization elements so as to discharge vaporized droplets of medicament from the associated vaporization chambers to produce the dosage of medicament indicated by the dosing directive;

wherein selectively transmitting electronic signals included transmitting electronic signals to a subset of vaporization elements so as to discharge vaporized droplets of medicament from a corresponding subset of vaporization chambers.

41. The method of claim 40, which further comprises altering the subset of vaporization chambers so as to alter the dosage of medicament produced during a dosing event.

42. The method of administering a dosage of a medicament to a patient, the method comprising:

exposing a volume of a medicament to a plurality of ejection elements;

selecting a nominal dosage of medicament to be ejected;

transmitting an ejection signal to at least one of the ejection elements, wherein the ejection signal is determined based on the selected nominal dosage; and

ejecting vaporized droplets of medicament from adjacent the ejection elements for respiration by the patient, dosage of medicament ejected being determined, at least in part, by frequency and quantity of ejection signals received by the ejection elements during a nominal dosage event.

43. A method of claim 42, which further comprises selecting a loading dosage, transmitting a loading ejection signal to at least one of the ejection elements based on such loading dosage, and ejecting vaporized droplets of medicament corresponding to such loading ejection signal in a loading dosage event, such loading dosage event preceding the dosing event.

44. The method of claim 42, which further comprises selecting a dosing ramp, determining progressive dosages along such dosing ramp, transmitting ejection signals based on such progressive dosages in successive dosing events, and in connection with each successive dosing event, ejecting vaporized droplets of medicament corresponding to the ejection signals of such dosing event.

45. A metered dose inhaler comprising:

an ejection mechanism including at least one vaporization chamber configured to contain a medicament, the ejection mechanism being configured to selectively effect controlled ejection of medicament from the at least one vaporization chamber; and

a controller configured to selectively send electronic signals to the ejection mechanism to direct ejection of medicament from the at least one vaporization chamber, such electronic signals being selectively alterable to effect change in medicament dosage, the controller further being configured to receive a nominal dosage, a prescribed dosage, and one or more dosage change parameters which effect a desired medicament delivery schedule that includes multiple different dosages which change according to a pre-programmed schedule, and wherein the controller is further configured a prescribed dosage, and to select a subset of plural vaporization elements receiving the electronic signals in accordance with such prescribed dosage.

46. A metered dose inhaler of claim 45, which further comprises an input in communication with the controller to identify the nominal dosage.

47. A metered dose inhaler of claim 45, wherein the one or more dosage change parameters includes a permissible dosage, and wherein the controller is further configured to restrict dosage according to such permissible dosage.

48. A metered dose inhaler of claim 45, wherein the one or more dosage change parameters includes a loading dosage, and wherein the controller is further configured to direct ejection of the loading dosage of medicament in a first dosing event followed by ejection of the nominal dosage of medicament in a second dosing event.

49. A metered dose inhaler of claim 45, wherein the one or more dosage change parameters includes a dosing ramp, and wherein the controller is further configured to direct ejection of progressive different dosages of medicament along such dosing ramp in successive dosing events.

50. The metered dose inhaler of claim 45, wherein the controller is further configured to receive prescription information for comparison to security check information, and to restrict changes in medicament dosage based on such comparison.