Systems and methods for modulation of pancreatic endocrine secretion and treatment of diabetes
First Claim
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1. A method of modulating pancreatic endocrine secretions of a patient, comprising:
- implanting at least one system control unit in the body of a patient, wherein the at least one unit controls the delivery of at least one stimulus to at least one type of pancreatic cell affecting pancreatic endocrine secretions; and
applying the at least one stimulus to the at least one type of pancreatic cell in order to hyperpolarize the at least one type of pancreatic cell and thereby modulate at least one pancreatic endocrine secretion;
wherein the at least one type of pancreatic cell is an alpha cell and wherein the hyperpolarization inhibits secretion of glucagon.
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Abstract
Systems and methods for introducing one or more stimulating drugs and/or applying electrical stimulation to the pancreas and/or nerve fibers innervating the pancreas to treat or prevent diabetes and/or to modulate pancreatic endocrine secretions uses at least one system control unit (SCU) producing electrical pulses delivered via electrodes and/or producing drug infusion pulses, wherein the stimulating drug(s) are delivered via one or more pumps and infusion outlets.
463 Citations
28 Claims
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1. A method of modulating pancreatic endocrine secretions of a patient, comprising:
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implanting at least one system control unit in the body of a patient, wherein the at least one unit controls the delivery of at least one stimulus to at least one type of pancreatic cell affecting pancreatic endocrine secretions; and
applying the at least one stimulus to the at least one type of pancreatic cell in order to hyperpolarize the at least one type of pancreatic cell and thereby modulate at least one pancreatic endocrine secretion;
wherein the at least one type of pancreatic cell is an alpha cell and wherein the hyperpolarization inhibits secretion of glucagon.
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2. A method of modulating pancreatic endocrine secretions of a patient, comprising:
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implanting at least one system control unit in the body of a patient, wherein the at least one unit controls the delivery of at least one stimulus to at least one type of pancreatic cell affecting pancreatic endocrine secretions; and
applying the at least one stimulus to the at least one type of pancreatic cell in order to hyperpolarize the at least one type of pancreatic cell and thereby modulate at least one pancreatic endocrine secretion;
wherein the at least one type of pancreatic cell is a delta cell and wherein the hyperpolarization inhibits secretion of somatostatin.
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3. A method of modulating pancreatic endocrine secretions of a patient, comprising:
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implanting at least one system control unit in the body of a patient, wherein the at least one unit controls the delivery of at least one stimulus to at least one type of pancreatic cell affecting pancreatic endocrine secretions; and
applying the at least one stimulus to the at least one type of pancreatic cell in order to depolarize the at least one type of pancreatic cell to thereby increase secretion of a substance that inhibits insulin secretion. - View Dependent Claims (4, 5)
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6. A method of modulating pancreatic endocrine secretions of a patient, comprising:
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implanting at least one system control unit in the body of a patient, wherein the at least one unit controls the delivery of simulation to at least one parasympathetic tissue innervating the pancreas; and
applying the stimulation to the at least one parasympathetic tissue in order to minimize stimulation of gastrointestinal structures and the heart while maximizing stimulation of pancreatic beta cells, whereby insulin secretion is modulated. - View Dependent Claims (7, 8, 9, 10, 11, 12)
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13. A method of modulating pancreatic endocrine secretions of a patient, comprising:
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implanting at least one system control unit in the body of a patient, wherein the at least one unit controls the delivery of stimulation to at least one sympathetic tissue innervating the pancreas; and
applying the stimulation to the at least one sympathetic tissue in order to modulate at least one pancreatic endocrine secretion;
wherein the at least one sympathetic tissue is at least one of the ganglia of the paraspinal sympathetic trunks, cellac ganglia, aorticorenal ganglia, super mesenteric ganglion, inferior mesenteric ganglion, phrenic ganglion, left greater splanchnic nerve, left lesser splanchnic nerve, left least splanchnic nerve, right greater splanchnic nerve, right lesser splanchnic nerve, and right least splanchnic nerve. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20)
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21. A method of modulating pancreatic endocrine secretions of a patient, comprising:
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implanting at least one system control unit in the body of a patient, wherein the at least one unit controls the delivery of drug stimulation to at least one area affecting pancreatic endocrine secretions; and
applying the drug stimulation to the at least one area in order to modulate at least one pancreatic endocrine secretion;
wherein the at least one system control unit is connected to at least one catheter, and wherein the stimulating drug is applied via the at least one catheter to at least one pancreatic islet or graft to increase insulin secretion, and wherein the drug is at least one of K+, Ca++, arginine, lysine, acetylcholine, a cholinergic agonist, a beta-adrenergic agonist, an alpha-adrenergic antagonist, glucagon-like peptide 1, gastric inhibitory peptide, secretin, cholecystokinin, and a beta-3-agonist. - View Dependent Claims (22)
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23. A method of modulating pancreatic endocrine secretions of a patient, comprising:
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implanting at least one system control unit in the body of a patient, wherein the at least one unit controls the delivery of drug stimulation to at least one area affecting pancreatic endocrine secretions; and
applying the drug stimulation to the at least one area in order to modulate at least one pancreatic endocrine secretion;
wherein the at least one system control unit is connected to at least one catheter, and wherein the stimulating drug is applied via the at least one catheter to at least one pancreatic islet or graft to inhibit insulin secretion, and wherein the drug is at least one of an alpha-adrenergic agonist, a chollnergic antagonist, a beta-adrenergic antagonist, galanic, oancreastatin, and leptin. - View Dependent Claims (24)
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25. A method of modulating pancreatic endocrine secretions of a patient, comprising:
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implanting at least one system control unit in the body of a patient, wherein the at least one unit controls the delivery of drug stimulation to at least one area affecting pancreatic endocrine secretions; and
applying the drug stimulation to the at least one area in order to modulate at least one pancreatic endocrine secretion;
wherein the at least one system control unit is connected to at least one catheter, and wherein the stimulating drug is applied via the at least one catheter to at least one pancreatic islet or graft to increase glucagon secretion, and wherein the drug is at least one of an alpha-adrenergic agonist, arginine, and alanine. - View Dependent Claims (26)
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27. A method of modulating pancreatic endocrine secretions of a patient, comprising:
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implanting at least one system control unit in the body of a patient, wherein the at least one unit controls the delivery of drug stimulation to at least one area effecting pancreatic endocrine secretions; and
applying the drug stimulation to the at least one area in order to modulate at least one pancreatic endocrine secretion;
wherein the at least one system control unit is connected to at least one catheter, and wherein the stimulating drug is applied via the at least one catheter to at least one pancreatic islet or graft to inhibit glucagon secretion, and wherein the drug is at least one of an alpha-adrenergic antagonist, glucose, and insulin. - View Dependent Claims (28)
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Specification