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Methods for selecting a therapy for a subject suffering from schizophrenia

  • US 6,833,243 B2
  • Filed: 08/16/2001
  • Issued: 12/21/2004
  • Est. Priority Date: 05/26/1994
  • Status: Expired due to Term
First Claim
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1. A method for selecting an efficacious therapy for a subject suffering from a schizophrenia, said method comprising the steps of:

  • (a) analyzing the MTHFR nucleic acid in a sample obtained from said subject;

    (b) determining the presence of a heterozygous C/T mutation at position 677 that decreases MTHFR activity or reduces MTHFR thermal dability MTHF in said subject, wherein the presence of said mutation is indicative of the efficacy of a therapy; and

    (c) selecting an efficacious neuroleptic therapy for said subject.

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