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Compositions and methods for generating chimeric heteromultimers

  • US 6,833,441 B2
  • Filed: 08/01/2001
  • Issued: 12/21/2004
  • Est. Priority Date: 08/01/2001
  • Status: Expired due to Term
First Claim
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1. A non-single-chain antigen-binding unit comprising:

  • (a) a light (L) chain polypeptide comprising a light (L) chain variable region fused in-frame to a first heterodimerization polypeptide;

    (b) a heavy (H) chain polypeptide comprising a heavy (H) chain variable region fused in-frame to a second heterodimerization polypeptide;

    wherein the L chain and the H chain polypeptides dimerize via pairwise affinity of the first and second heterodimerization polypeptides; and

    wherein at least one of the heterodimerization polypeptides is essentially incapable of fanning a homodimer under physiological buffer conditions and/or at physiological body temperatures.

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