Method and device for abrading skin

• US 6,835,184 B1
• Filed: 09/24/1999
• Issued: 12/28/2004
• Est. Priority Date: 09/24/1999
• Status: Expired due to Term

• Current Assignee: Becton, Dickinson & Co
• Original Assignee: Becton, Dickinson & Co
• Inventors: Bock, Carl Randolph, Sage, Burton H.
• Primary Examiner(s): Casler, Brian L.
• Assistant Examiner(s): Thissell, Jeremy
• Application Number:
  US09/405,488
• Time in Patent Office: 1,922 Days
• Field of Search: 604/20, 604/46, 604/47, 604/239, 604/272, 604/890.1
• US Class Current: 604/46
• CPC Class Codes: A61B 17/205 Vaccinating by means of needles or other puncturing devices
• CPC Class Codes: A61B 17/54 Chiropodists' instruments , e.g. pedicure chiropractic devices A61H1/008
• CPC Class Codes: A61B 2017/00761 Removing layer of skin tissue, e.g. wrinkles, scars or cancerous tissue
• CPC Class Codes: A61B 2017/320004 abrasive
• CPC Class Codes: A61M 2037/0007 having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
• CPC Class Codes: A61M 2037/0046 Solid microneedles
• CPC Class Codes: A61M 2037/0053 Methods for producing microneedles
• CPC Class Codes: A61M 2037/0061 Methods for using microneedles
• CPC Class Codes: A61M 37/0015 by using microneedles
• CPC Class Codes: A61N 1/303 Constructional details electrodes for external use A61N1/0428

Abstract

A device includes a plurality of microneedles for abrading the stratum corneum of the skin to form a plurality of grooves in the tissue having a controlled depth and width. The microneedles have a length of about 5-250 microns and generally about 5-200 microns. The device is rubbed over the skin to prepare an abraded site after which a transdermal delivery or sampling device is applied to the abraded delivery site. The abrasion increases the permeability of the skin and the rate of delivery and extraction of a substance without pain or irritation to the patient.

Claims

1. A method for the delivery of a substance to a patient, said method comprising:

positioning a microabrader at a delivery site on the skin of a patient, said microabrader having a support and a plurality of microneedles coupled to said support, each of said microneedles having a length greater than the thickness of the stratum corneum;

moving said microabrader across the skin of the patient to allow the microneedles to penetrate into the stratum corneum substantially without piercing the stratum corneum and thereby abrade said stratum corneum at said delivery site to increase the permeability of said skin to said substance; and

applying said substance to said delivery site to transfer said substance through the stratum corneum and into said skin.

2. The method of claim 1, wherein said microneedles are about 50 to about 250 microns in length.

3. The method of claim 1, wherein said microneedles are arranged in an array of columns and rows and are substantially uniformly spaced apart.

4. The method of claim 1, wherein each of said microneedles has a substantially frustoconical shape terminating in a blunt tip.

5. The method of claim 1, wherein said moving step comprises moving said microabrader in one direction in a substantially straight line to form a plurality of spaced-apart grooves on the skin.

6. The method of claim 5, comprising the further steps of repositioning said microabrader at said delivery site and again moving said microabrader in said straight line.

7. The method of claim 1, comprising the further steps of removing said microabrader from said delivery site, and applying a drug delivery device to said delivery site.

8. The method of claim 7, wherein said drug delivery device comprises an iontophoresis device.

9. The method of claim 1, wherein said abraded delivery site comprises an area of skin having a plurality of substantially parallel grooves separated by peaks.

10. The method of claim 7, wherein said drug delivery device comprises a passive delivery device.

11. The method of claim 1, wherein each of said microneedles has a plurality of side walls extending from said support and terminating in a blunt tip.

12. The method of claim 11, wherein said blunt tip has a substantially flat face that is substantially parallel to said support.

13. The method of claim 12, wherein said flat face of said tip joins each of said side walls along an abrading edge.

14. The method of claim 11, wherein each of said side walls is joined to an adjacent side wall along an abrading edge.

15. A method of treating the skin of a patient to enhance transdermal delivery of a substance or the withdrawal of said substance from the body of said patient, said method comprising:

positioning a microabrader at a treatment site on the skin of said patient, said microabrader having a plurality of microneedles, each of said microneedles having a length greater than the thickness of the stratum corneum; and

moving said microabrader across the skin of the patient to allow said microneedles to penetrate into said stratum corneum substantially without piercing said stratum corneum and thereby abrade said skin and form an abraded area, said abraded area having a plurality of grooves formed in said stratum corneum from abrasion by said microneedles.

16. The method of claim 15, wherein said microneedles are about 50 to about 250 microns in length, are arranged in a plurality of columns and rows, and are substantially uniformly spaced apart.

17. The method of claim 15, wherein each of said microneedles has a substantially frustoconical shape terminating in a blunt tip.

18. The method of claim 15, comprising the further steps of repositioning said microabrader at said delivery site and again moving said microabrader over the same area of the skin.

19. The method of claim 15, wherein each of said microneedles has a plurality of side walls extending from a planar support and terminating at a blunt tip.

20. The method of claim 19, wherein said blunt tip has a substantially flat face that is substantially parallel to said planar support.

21. The method of claim 20, wherein said flat face of said tip joins each of said side walls along an abrading edge.

22. The method of claim 19, wherein each of said side walls is joined to an adjacent side wall along an abrading edge.

23. A method of treating the skin of a patient to reduce the electrical resistance of the skin at a treatment site, said method comprising:

positioning a microabrader having a plurality of microneedles at said treatment site, each of said microneedles having a length greater than the thickness of the stratum corneum;

moving said microabrader across the skin of the patient to allow the microneedles to penetrate into the stratum corneum substantially without piercing the stratum corneum and thereby abrade said stratum corneum on said treatment site;

placing a signal electrode at or near-the prepared treatment site; and

recording at least one signal from said electrode.

24. The method of claim 23, wherein said abrading step abrades the stratum corneum on the treatment site substantially without piercing the stratum corneum.

25. The method of claim 23, comprising the step of moving the microabrader on the skin of the patient to form a plurality of grooves in the stratum corneum, said grooves having a depth to penetrate the stratum corneum substantially without piercing the stratum corneum.