Methods for treating sleep apnea and sleep induced apnea using optically pure (+) norcisapride

• US 6,835,740 B2
• Filed: 02/15/2002
• Issued: 12/28/2004
• Est. Priority Date: 06/15/1998
• Status: Expired due to Fees

• Current Assignee: Sepracor Incorporated (Sumitomo Chemical Company Limited)
• Original Assignee: Sepracor Incorporated (Sumitomo Chemical Company Limited)
• Inventors: Barberich, Timothy J., Rubin, Paul D.
• Primary Examiner(s): Cook, Rebecca
• Application Number:
  US10/075,617
• Publication Number:
  US 20020147220A1
• Time in Patent Office: 1,047 Days
• Field of Search: 514/327
• US Class Current: 514/327
• CPC Class Codes: A61K 31/445 Non condensed piperidines, e.g. piperocaine
• CPC Class Codes: A61K 31/4468 having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 13/10 of the bladder
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/06 Antiarrhythmics

Abstract

Methods for the prevention, treatment, or management of apnea, apnea disorders, bulimia, nervosa, irritable bowel syndrome, urinary incontinence, bradycardia, bradyarrhythmia, syncope, other disorders, or symptoms thereof using (+) norcisapride, or a pharmaceutically acceptable salt thereof, substantially free of its (−) stereoisomer.

Claims

1. A method of treating sleep apnea or sleep induced apnea in a patient which comprises administering to a patient in need of said treatment a therapeutically effective amount of (+) norcisapride, or a pharmaceutically acceptable salt thereof, substantially free of its (−

) stereoisomer.

2. The method of claim 1, wherein the patient is a human.

3. The method of claim 1, wherein (+) norcisapride is administered orally.

4. The method of claim 3, wherein (+) norcisapride is administered as a tablet or a capsule.

5. The method of claim 1, wherein the amount administered is from about 0.5 mg to about 500 mg.

6. The method of claim 5, wherein the amount administered is from about 1 mg to about 250 mg.

7. The method of claim 1, wherein (+) norcisapride is administered together with a pharmaceutically acceptable carrier.

8. The method of claim 3, wherein said (+) norcisapride is administered from one to four times per day.

9. The method of claim 1, wherein (+) norcisapride is administered parenterally, transdermally, rectally or sublingually.

10. A method of managing sleep apnea or sleep induced apnea in a patient which comprises administering to a patient in need of said management a therapeutically effective amount of (+) norcisapride, or a pharmaceutically acceptable salt thereof, substantially free of its (−

) stereoisomer.

11. The method of claim 10, wherein the patient is a human.

12. The method of claim 10, wherein (+) norcisapride is administered orally.

13. The method of claim 12, wherein (+) norcisapride is administered as a tablet or a capsule.

14. The method of claim 10, wherein the amount administered is from about 0.5 mg to about 500 mg.

15. The method of claim 14, wherein the amount administered is from about 1 mg to about 250 mg.

16. The method of claim 10, wherein (+) norcisapride is administered together with a pharmaceutically acceptable carrier.

17. The method of claim 12, wherein said (+) norcisapride is administered from one to four times per day.

18. The method of claim 10, wherein (+) norcisapride is administered parenterally, transdermally, rectally or sublingually.