Non-invasive blood glucose monitoring by interferometry

• US 6,836,337 B2
• Filed: 09/19/2002
• Issued: 12/28/2004
• Est. Priority Date: 09/20/2001
• Status: Expired due to Fees

• Current Assignee: Visual Pathways, Inc.
• Original Assignee: Visual Pathways, Inc.
• Inventors: Cornsweet, Tom N.
• Primary Examiner(s): Smith, Zandra V.
• Assistant Examiner(s): LEE, HWA S
• Application Number:
  US10/247,753
• Publication Number:
  US 20030076508A1
• Time in Patent Office: 831 Days
• Field of Search: 356/450, 356/517, 356/481
• US Class Current: 356/517
• CPC Class Codes: A61B 3/152 for aligning
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters

Abstract

The glucose concentration in the bloodstream is directly correlated to the concentration of glucose in the aqueous humor. Furthermore, variation in the glucose concentration in the aqueous humor will cause like variations in its index of refraction. Thus, by measuring the refractive index of the aqueous humor, the glucose concentration in the blood can be determined.

The refractive index of the aqueous humor can be measured by interferometry. In various embodiments of the invention that employ interferometry, two beams may be directed onto the eye and caused to interfere, thereby producing a fringe pattern. The fringe pattern may be analyzed to determine the index of refraction of the aqueous humor in the eye and the glucose concentration therein. The glucose level in the blood can be ascertained from this information.

Claims

1. A method of measuring glucose levels in blood of a living being having an eye comprising a cornea and a lens, which together form an anterior chamber, said eye further comprising an iris and aqueous humor in said anterior chamber, said aqueous humor having an index of refraction correlated to said glucose level in said blood, said method comprising:

propagating two substantially coherent beams of light through said cornea to illuminate a region of said iris, said two substantially coherent beams of light propagating through said aqueous humor to reach said iris;

overlapping said two beams on said region of said iris, said two beams being sufficiently coherent so as to produce an interference pattern in said region of said iris, said interference pattern comprising a plurality of fringes having a spatial arrangement that depends on said index of refraction of said aqueous humor;

imaging said interference pattern onto a light sensitive optical detector; and

determining said glucose level in said blood from said spatial arrangement of said fringes in said interference pattern.

2. The method of claim 1, wherein said glucose level is determined at least in part by identifying the locations of extrema in said spatial arrangement of said fringes.

3. The method of claim 1, wherein said glucose level is determined at least in part from the fringe spacing.

4. The method of claim 1, wherein said glucose level is determined at least in part by fitting at least a cross-sectional profile of said fringe pattern to a curve.

5. The method of claim 1, wherein said glucose level is determined at least in part by matching a profile of said fringe patterns to known profiles in a look-up table.

6. An apparatus for monitoring glucose fluctuations by measuring properties of an eye, said apparatus comprising:

a light source which emits a beam of light;

an optical element situated to receive said beam of light from said light source and to split said beam of light into first and second probe beams that propagate along respective first and second optical paths;

at lease one optical element in one of said optical paths to alter said optical path such that first and second probe beams intersect at a target plane;

an optical detector and imaging optics for imaging said target plane on said optical detector;

an alignment system for aligning said first and second probe beams with said eye, said alignment system including an optical sensor having an electronic output indicative of the state of alignment; and

an alignment system for aligning said first and second probe beams with said eye, said alignment system including an optical sensor having an electronic output indicative of the state of alignment; and

electronics electrically coupled to (i) said electronic output of said optical sensor included in said alignment system and to (ii) said optical detector that images said target plane, said electronics configured to cause said optical detector to capture an image of said target plane based on said state of alignment.

7. The apparatus of claim 6, wherein said light source comprises a laser.

8. The apparatus of claim 6, wherein said optical element situated to receive said beam of light from said light source comprises a beamsplitter.

9. The apparatus of claim 6, wherein said at least one optical element that alters said optical path such that said first and second probe beams intersects comprises a mirror.

10. The apparatus of claim 6, wherein said imaging optics includes a lens.

11. The apparatus of claim 6, further comprising focusing optics in said second optical path that transforms said second optical beam into a converging beam.

12. The apparatus of claim 11, wherein said eye includes a cornea having a curved outer surface defined by a center of curvature and said focusing optics configured and situated to transform said second optical beam into a converging beam comprising wavefronts having a center of curvature substantially coincident with the center of curvature of said outer surface of said cornea.

13. The apparatus of claim 6, wherein said optical detector and said imaging optics are arranged together with said target plane to satisfy the Scheimpflug condition.

14. A method of monitoring glucose levels in blood of a living being having an eye, said method comprising:

propagating light through a portion of said eye comprising aqueous is humor having an index of refraction that varies with glucose concentration;

obtaining phase information associated with said light through optical interference, said phase information depending at least in part on said index of refraction of said aqueous humor;

said step of obtaining phase information comprising analyzing interference fringes.

15. The method of claim 14, further comprising correlating said phase information with at least one independently measured glucose level of said living being to provide calibration.

16. An apparatus for monitoring glucose fluctuations by measuring properties of an eye said apparatus comprising:

a light source which emits a beam of light;

an optical element situated to receive said beam of light from said light source and to split said beam of light into first and second probe beams that propagate along respective first and second optical paths;

focusing optics in said optical path that transforms said second optical beam into a converging beam;

at least one optical element in one of said optical paths to alter said optical path such that first and second probe beams intersect at a target plane;

an optical detector and imaging optics for imaging said target plane on said optical detector; and

said eye including a cornea having a curved outer surface defined by a center of curvature and said focusing optics being configured and situated to transform said second optical beam into a converging beam comprising wavefronts having a center of curvature substantially coincident with the center of curvature of said outer surface of said cornea.

17. The apparatus of claim 16, wherein said optical detector and said imaging optics are arranged together with said target plane to satisfy the Scheimpflug condition.