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Diffraction system for biological crystal screening

  • US 6,836,532 B2
  • Filed: 04/09/2002
  • Issued: 12/28/2004
  • Est. Priority Date: 06/29/2001
  • Status: Active Grant
First Claim
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1. A sample container for containing a sample during monitoring of crystal formation in a crystal growth medium by transmission of x-ray energy from an x-ray source on a first side of the container to he sample, presence of crystalline material resulting in diffraction of the x-ray energy toward a detector located on a second side of the container opposite the first side, the sample container comprising:

  • a reservoir region within the container in which a well solution may be located for inducing evaporation of a liquid portion of the sample by vapor diffusion; and

    a platform within the container upon which the sample resides during monitoring under the force of gravity, wherein the reservoir region and the platform are arranged such that a beam of said x-ray energy travels from the x-ray source through the platform to the sample location without being incident on the well solution, the platform being physically separated from the first side of the container such that the x-ray beam passes through a region of the container having no solid material prior to encountering the platform.

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