Non-invasive blood glucose monitor

• US 6,836,678 B2
• Filed: 02/13/2003
• Issued: 12/28/2004
• Est. Priority Date: 02/13/2003
• Status: Expired due to Fees

• Current Assignee: Xiang Zheng Tu
• Original Assignee: Xiang Zheng Tu
• Inventors: Tu, Xiang Zheng
• Primary Examiner(s): Winakur, Eric F.
• Assistant Examiner(s): KREMER, MATTHEW J
• Application Number:
  US10/368,813
• Publication Number:
  US 20040162470A1
• Time in Patent Office: 684 Days
• Field of Search: 600/316, 600/365, 600/473, 600/309-310
• US Class Current: 600/316
• CPC Class Codes: A61B 2562/12 Manufacturing methods specially adapted for producing sensors for in-vivo measurements
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters

Abstract

A micro-optical-mechanical-electro-system (MOMES)-based non-invasive blood glucose monitor comprises a micromachined infrared optical filter array, a micromachined infrared mechanical modulator array, at least one micromachined infrared tunable filter, and at least one infrared detector. Each optical filter is aligned with a mechanical modulator along its optical axis direction. The optical filter continuously divides a monochromatic infrared light in a wavelength range within 0.8 to 25 micron from an infrared light. The aligned mechanical modulator turns the monochromatic infrared light into an alternating monochromatic infrared light. The tunable filter is aligned with the infrared detector along its optical axis direction. The tunable filter selects the back-diffused alternating monochromatic infrared light emitted from a measured blood subject that is illuminated by the alternating monochromatic infrared light. The infrared detector converts the back-diffused alternating monochromatic infrared light into an alternating electronic signal. Then a photo-integrated circuit (IC) combines with the infrared detector for synchronous detection and amplification of the electronic signal generated by the synchronous detection.

Claims

1. A micro-optical-mechanical-electro-system (MOMES)-based non-invasive blood glucose monitor comprising:

a micromachined infrared optical filter array each for continuously dividing an infrared light in a wavelength range within 0.8 to 25 micron from an infrared light,

a micromachined infrared mechanical modulator array each for turning the infrared light into an alternating infrared light,

at least one micromachined infrared tunable filter for selecting back-diffused alternating monochromatic infrared light emitted from a measured blood subject that is illuminated by the alternating infrared light,

three driver circuits for actuating the optical filter array, mechanical modulator array, and tunable filter, respectively,

at least one infrared detector for converting the back-diffused alternating monochromatic infrared light into an alternating electronic signal,

at least one infrared light source for irradiating the infrared light,

at least one collimator enabling the incoming infrared light to run parallel to its optic axis, and

a photo-integrated circuit (IC) combining with the infrared detector for synchronous detection and amplification of the electronic signal generated by the synchronous detection.

2. The MOMES-based non-invasive blood glucose monitor as claimed in claim 1, further comprising:

an infrared band pass filter for selecting an infrared light in a wavelength range within 0.8 to 25 micron,

a data processing circuit consisting of an analog multiplexer circuit, a sample-and-hold circuit, and an analog to digital converter for providing a digital output, and

a microprocessor for determining the glucose concentration of the measured blood subject.

3. The MOMES-based non-invasive blood glucose monitor as claimed in claim 1, wherein each of said micromachined infrared optical filter array, each of said micromachined infrared mechanical modulator array, and said micromachined infrared tunable filter respectively consists of an air gap variable Fabry-Perot cavity that is defined by two parallel planar reflectors.

4. The MOMES-based non-invasive blood glucose monitor as claimed in claim 1, wherein said infrared light source is a metal wire or metal foil lamp.

5. The MOMES-based non-invasive blood glucose monitor as claimed in claim 1, wherein said infrared light source is a thin film radiator array.

6. The MOMES-based non-invasive blood glucose monitor as claimed in claim 1, wherein said infrared detector is a photoconductive sensor.

7. The MOMES-based non-invasive blood glucose monitor as claimed in claim 1, wherein said infrared detector is a micromachined thermopile.

8. The MOMES-based non-invasive blood glucose monitor as claimed in claim 1, wherein said infrared detector is a micromachined bolometer.

9. A micro-optical-mechanical-electro-system (MOMES)-based infrared device assembly for a non-invasive blood glucose monitor comprising:

a micromachined infrared optical filter array each for continuously dividing an infrared light in a wavelength range within 0.8 to 25 micron from an infrared light,

a micromachined infrared mechanical modulator array each for turning the infrared light into an alternating infrared light,

at least one micromachined infrared tunable filter for selecting back-diffused alternating monochromatic infrared light emitted from a measured blood subject that is illuminated by the alternating infrared light,

three driver circuits for actuating the optical filter array, mechanical modulator array, and tunable filter, respectively,

at least one infrared detector for converting the back-diffused alternating monochromatic infrared light into an alternating electronic signal,

at least one infrared light source for irradiating the infrared light,

at least one collimator enabling the incoming infrared light to run parallel to its optic axis, and

a photo-integrated circuit (IC) combining with the infrared detector for synchronous detection and amplification of the electronic signal generated by the synchronous detection.

10. The MOMES-based infrared device assembly for a non-invasive blood glucose monitor as claimed in claim 9, wherein each of said micromachined infrared optical filter array, each of said micromachined infrared mechanical modulator array, and said micromachined infrared tunable filter respectively consists of an air gap variable Fabry-Perot cavity that is defined by two parallel planar reflectors.

11. The MOMES-based infrared device assembly for a non-invasive blood glucose monitor as claimed in claim 9, wherein said infrared light source is a metal wire or metal foil lamp.

12. The MOMES-based infrared device assembly for a non-invasive blood glucose monitor as claimed in claim 9, wherein said infrared light source is a thin film radiator array.

13. The MOMES-based infrared device assembly for a non-invasive blood glucose monitor as claimed in claim 9, wherein said infrared detector is a photoconductive sensor.

14. The MOMES-based infrared device assembly for a non-invasive blood glucose monitor as claimed in claim 9, wherein said infrared detector is a micromachined thermopile.

15. The MOMES-based infrared device assembly for a non-invasive blood glucose monitor as claimed in claim 9, wherein said infrared detector is a micromachined bolometer.

16. A micro-optical-mechanical-electro-system (MOMES)-based non-invasive blood glucose measurement method comprising steps:

actuating one of a micromachined infrared optical filter array for continuously dividing an infrared light in a wavelength range within 0.8 to 25 micron from an infrared light source,

actuating one of a micromachined infrared mechanical modulator array for turning the infrared light into an alternating infrared light,

actuating at least one micromachined tunable filter for selecting back-diffused alternating monochromatic infrared light emitted from a measured blood subject that is illuminated by the alternating infrared light,

using at least one infrared detector to convert the back-diffused alternating monochromatic infrared light into an alternating electronic signal, and

performing synchronous detection of the alternating electronic signal and amplification of the electronic signal generated by the synchronous detection.

17. The MOMES-based non-invasive blood glucose measurement method as claimed in claim 16, wherein each of said micromachined infrared optical filter array, each of said micromachined infrared mechanical modulator array, and said micromachined infrared tunable filter respectively consists of an air gap variable Fabry-Perot cavity that is defined by two parallel planar reflectors.

18. The MOMES-based non-invasive blood glucose measurement method as claimed in claim 16, wherein said infrared light source is a metal wire or metal foil lamp.

19. The MOMES-based non-invasive blood glucose measurement method as claimed in claim 16, wherein said infrared light source is a thin film radiator array.

20. The MOMES-based non-invasive blood glucose measurement method as claimed in claim 16, wherein said infrared detector is a photoconductive sensor.

21. The MOMES-based non-invasive blood glucose measurement method as claimed in claim 16, wherein said infrared detector is a micromachined thermopile.

22. The MOMES-based non-invasive blood glucose measurement method as claimed in claim 16, wherein said infrared detector is a micromachined bolometer.