Method to control an overactive bladder

• US 6,836,684 B1
• Filed: 07/30/2001
• Issued: 12/28/2004
• Est. Priority Date: 10/30/1998
• Status: Expired due to Term

• Current Assignee: Neurodan AS
• Original Assignee: Neurocon APS
• Inventors: Grill, Warren, Rijkhoff, Nico J. M., Jezernik, Saso, Sinkjaer, Thomas
• Primary Examiner(s): Jastrzab, Jeffrey R.
• Assistant Examiner(s): Oropeza, Frances P.
• Application Number:
  US09/830,666
• Time in Patent Office: 1,247 Days
• Field of Search: 600/363, 600/377, 607/40, 607/41, 607/115, 607/116
• US Class Current: 607/40
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control

Abstract

A method to control an overactive bladder and to estimate bladder volume using an implanted sensor having at least one nerve electrode to sense electrical signals. The method includes detecting events from nerve signals, generating electrical pulses for stimulating nerves, and stimulating the nerves to inhibit detrusor contraction. Bladder volume may also be estimated based on the amplitude of the detected nerve signals and/or the time between two detected nerve signals from consecutive detrusor contractions.

Claims

1. A method for controlling an overactive bladder, comprising the steps:

detecting nerve signals from nerves innervating the bladder;

detecting a bladder event from the nerve signals;

generating electrical pulses in response to the detected event;

stimulating afferent nerves using the generated electrical pulses in order to inhibit detrusor contraction of the bladder.

2. A method as defined in claim 1, wherein the detected nerve signals primarily come from afferent nerve fibres innervating mechanoreceptors in the bladder wall.

3. A method as defined in claim 1, wherein the detected nerve signals come from efferent nerve fibres innervating the bladder.

4. A method as defined in claim 1, wherein two different signals are used to detect detrusor contractions, a first signal coming from afferent nerves innervating the bladder, and a second signal coming from efferent nerves innervating the detrusor muscle.

5. A method as defined in claim 1, wherein neural circuits inhibiting bladder contraction are stimulated by activating an inhibitory spinal reflex by stimulating afferent nerve fibres innervating mechanoreceptors located in the glans of the penis or clitoris.

6. A method as defined in claim 5, wherein a stimulation electrode is located at a nerve belonging to the group consisting of a dorsal penile/clitoris nerve, a pudendal nerve, an extradural sacral nerve root and an intradural dorsal sacral nerve root.

7. A method as defined in claim 1, wherein both a detecting electrode and a stimulation electrode are located at either the intradural dorsal sacral nerve roots or the extradural sacral nerve root.

8. A method as defined in claim 7, wherein the dorsal sacral nerve roots belong to the group S2-S4.

9. The method as set forth in claim 1, further comprising the step of estimating bladder volume in response to the detected signals using signal-processing methods.

10. The method as set forth in claim 9, wherein said step of estimating is performed using an amplitude of the detected nerve signals.

11. The method as set forth in claim 9, wherein said step of estimating is performed using a time between two detected nerve signals derived from two consecutive detrusor contractions.

12. The method as set forth in claim 9, wherein said step of estimating is performed using an amplitude of the detected nerve signals and a time between two detected nerve signals derived from two consecutive detrusor contractions.

13. The method as set forth in claim 9, further comprising the steps of:

transmitting, from a transmitter placed inside a user'"'"'s body, a signal when a predetermined threshold value for bladder volume has been exceeded;

receiving the signal with a receiver located outside the user'"'"'s body;

actuating an alert in response to the received signal for alerting the user that the threshold value has been reached.