Programmable electronic maze for use in the assessment of animal behavior

• US 6,837,184 B2
• Filed: 08/05/2002
• Issued: 01/04/2005
• Est. Priority Date: 08/06/2001
• Status: Active Grant

• Current Assignee: PsychoGenics Inc.
• Original Assignee: PsychoGenics Inc.
• Inventors: Gondhalekar, Vijay, Brunner, Daniela
• Primary Examiner(s): Luu, Teri P.
• Assistant Examiner(s): SHAW, ELIZABETH ANNE
• Application Number:
  US10/212,834
• Publication Number:
  US 20030024482A1
• Time in Patent Office: 883 Days
• Field of Search: 119/416, 119/417, 119/421, 119/452, 273/110, 273/109, 472/62, 472/86, 463/15, 52/65
• US Class Current: 119/421
• CPC Class Codes: A01K 1/031 Cages for laboratory animals; Cages for measuring metabolism of animals
• CPC Class Codes: A01K 1/035 Devices for use in keeping domestic animals, e.g. fittings in housings or dog beds
• CPC Class Codes: A01K 15/02 Training or exercising equipment, e.g. mazes or labyrinths for animals A01K15/04 takes precedence; Electric shock devices circuits therefor H03K3/537; Toys specially adapted for animals
• CPC Class Codes: A01K 29/005 Monitoring or measuring activity, e.g. detecting heat or mating
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00

Abstract

A system and method for studying a test subject includes monitoring the test subject as it traverses through a programmable maze. The test subject may be under the influence of experimental drugs or genetic manipulation. The dynamic maze can be changed automatically or manually to test the abilities of the test subject. The dynamic maze comprises of a starting point, an ending point, and an electronically programmable floor capable of constructing various obstacles and passageways. The programmable floor may be programmed by a human user using an interface, or it may be programmed by an automated control system that programs the maze in accordance with the ability of the test subject to traverse the maze. Various devices are incorporated with the use of the maze to monitor the activities and welfare of the test subject.

Claims

1. A dynamic maze, comprising:

an interior maze volume defined by multiple boundary surfaces; and

at least two removable obstacles under control of a programmable system that configures the maze by inserting or removing at least one of the at least two obstacles through a boundary surface of the maze.

2. The maze according to claim 1, further comprising:

a logic component that configures the maze and is responsive to ability of a test subject to traverse the maze.

3. The maze according to claim 2, further comprising:

a clock component for measuring time required by the test subject to traverse all or a portion of the maze such that the logic component receives time data for use in determining configuration of the maze.

4. The maze according to claim 1, wherein the obstacle transmits a primary stimulus to a test subject in a rewarding or noxious manner.

5. The maze according to claim 4, further comprising:

a secondary stimulus that can reinforce or conflict with the primary stimulus.

6. The maze according to claim 1 further comprising:

a monitor to observe behavior of a test subject.

7. The maze according to claim 6 wherein the monitor records movements of the test subject.

8. The maze according to claim 1 wherein the obstacle is configured to impede ability of a test subject to traverse said obstacle.

9. The maze according to claim 1 wherein the obstacle is configured to preclude a test subject from traversing said obstacle.

10. The maze according to claim 1, further comprising:

a starting point and an end point.

11. The maze according to claim 10, wherein said starting point stimulates a punishment for a test subject.

12. The maze according to claim 10, wherein said end point stimulates a reward for a test subject.

13. The maze according to claim 1 further comprising flooring sensors for detecting location of a test subject.

14. The maze according to claim 1 further comprising temperature sensors for detecting ambient temperature and temperature of a test subject.

15. The maze according to claim 1 further comprising weight sensors for detecting weight of a test subject.

16. The dynamic maze according to claim 1, wherein at least two of said obstacles can be removed through one of the following:

the outer walls, the floor, or the ceiling, encompassing said maze.

17. The dynamic maze according to claim 1, wherein in at least one case, removing said obstacle, positions said obstacle parallel to said floor or said ceiling.

18. A dynamic maze, comprising:

an enclosure, for holding a test subject, defined by multiple boundary surfaces; and

at least two removable obstacles under control of a programmable system that configures the maze by inserting or removing at least one of the at least two obstacles through a boundary surface of the maze.

19. The dynamic maze according to claim 18, wherein the enclosure is a cage suitable for housing a laboratory animal.

20. The dynamic maze according to claim 19, wherein the enclosure is portable.

21. The dynamic maze according to claim 18, wherein the maze is configured to concurrently study a plurality of test subjects.

22. The dynamic maze according to claim 18 further comprising:

a laboratory animal test subject.

23. The dynamic maze according to claim 22, wherein the laboratory animal is a mouse.

24. The device according to claim 18 further comprising:

raised stilts positioned to require a test subject to move from one stilt to the next.

25. The device according to claim 24 wherein at least some of the raised stilts are raised to a uniform height and angle.

26. The device according to claim 24 wherein the raised stilts are arranged relative to each other so as to cause the test subject to move by placing one foot on a first stilt and another foot on a second stilt and then move the one foot to a different stilt.

27. A dynamic maze, comprising:

an enclosure, for holding a test subject, defined by multiple boundary surfaces;

a maze having at least two removable obstacles under control of a programmable system that configures the maze by inserting or removing at least one of the at least two obstacles through a boundary surface of the maze ; and

a controller having a logic system configured to control design of the maze without manual input from a user.

28. A dynamic maze for studying a test subject, comprising:

a programmable flooring having a plurality of floor plates such that each floor plate is capable of being a reward or punishment to the test subject traversing the maze.

29. The maze of claim 28 wherein the flooring is programmable manually by a user.

30. The maze according to claim 28 wherein the flooring is responsive to the behavior of the test subject traversing the maze.

31. A dynamic maze, comprising:

an interior maze volume defined by multiple boundary surfaces;

at least two removable obstacles under control of a programmable system that configures the maze by inserting or removing at least one of the at least two obstacles through a boundary surface of the maze; and

a controller having a logic system configured to control design of the maze.

32. The maze according to claim 31 further comprising:

at least one tube disposed thereon, the tube configured to entrap a test subject such that the test subject can only traverse through the tube in one direction.

33. The maze according to claim 32 wherein two or more tubes are interconnected.

34. The maze according to claim 32 wherein at least one tube is rotatable.

35. The maze according to claim 32, wherein the tube further comprises:

at least one floor plate capable of being an obstacle.

36. The maze according to claim 31, further comprising:

at least one incline means, the incline means configured to be an obstacle to a test subject in the maze such that the incline means is responsive to ability of the test subject to traverse through the maze.

37. The maze according to claim 36, wherein the incline means comprises:

at least one floor plate.

38. The maze according to claim 31, further comprising:

at least one flooring such that the flooring is movable for creating an obstacle for a test subject traversing through the maze.

39. The maze according to claim 31, wherein the flooring further comprises:

at least one stilt that is rotatable about the flooring such that the stilt creates an obstacle for a test subject.

40. The maze according to claim 39, wherein the stilt is adjustable to various angles in relationship to the flooring.

41. The maze according to claim 31, further comprising:

a collapsible flooring, the flooring being able to expose a wall that creates an obstacle for the test subject.

42. The maze according to claim 41, further comprising:

a user interface for manual operation of the collapsible flooring.

43. The maze according to claim 41, wherein the controller controls the collapsible floor based on the behavior of the test subject traversing the maze.

44. The maze according to claim 31, further comprising:

an integrated light source in at least one floor plate.

45. The maze according to claim 44 wherein intensity of said integrated light source is variable.

46. The maze according to claim 44 wherein intensity of said integrated light source is programmable by said controller.

47. The maze according to claim 31, further comprising:

a shock providing mechanism.

48. The maze according to claim 47 wherein intensity of said shock providing mechanism is variable.

49. The maze according to claim 47 wherein intensity of said shock providing mechanism is programmable by said controller.

50. A method of re-configuring a maze, comprising:

receiving data from a test subject in the maze; and

re-configuring design of the maze by inserting or removing at least one obstacle from the maze through a boundary surface of the maze, based on the data without intervention from a user.

51. The method according to claim 50, wherein the data is transmitted from the maze.

52. A method of assessing the ability of a test subject to solve a maze, comprising:

delivering at least one of rewarding or noxious stimulus to the test subject depending on path taken by the test subject in the maze; and

re-configuring the maze without user intervention based on ability of the test subject to traverse through the maze.

53. The method of claim 52 further comprising the step of:

delivering a secondary stimulus to the test subject to enforce or conflict effect of said rewarding or noxious stimulus.

54. A method to assess ability of an animal to solve mazes of differing complexities, comprising:

recording ability of a test subject to traverse through a maze; and

re-configuring the maze without user intervention to various levels of complexity based on the ability of the test subjects to traverse the maze.

55. The method of claim 54 further comprising the step of:

delivering rewarding or noxious stimulus to the test subject depending on path taken by the test subject in the maze.

56. The method of claim 54 further comprising the step of:

measuring time required by the animal to solve the maze.

57. A dynamic maze, comprising:

an interior maze volume defined by multiple boundary surfaces; and

at least two removable obstacles under control of a programmable system that configures the maze by inserting or removing at least one of the at least two obstacles through a boundary surface of the maze such that the maze rapidly re-configures for measurement of different behavioral responses of a test subject.

58. The dynamic maze according to claim 57, wherein the obstacle vibrates.

59. The dynamic maze according to claim 57, wherein the obstacle is a moving single floor.

60. The dynamic maze according to claim 59, wherein the flooring moves in a single direction.

61. The dynamic maze according to claim 59, wherein the flooring moves in multiple directions.

62. The dynamic maze according to claim 57, wherein the obstacle further comprises:

a plurality of moving floor plates.

63. The dynamic maze according to claim 62, wherein the floor plates move in concert.

64. The dynamic maze according to claim 62, wherein the floor plates move individually such that at least one floor plate is still and at least another floor plate is moving.

65. The dynamic maze according to claim 62, wherein the floor plates move individually.

66. The dynamic maze according to claim 62, wherein the floor plates move in different directions.

67. The dynamic maze according to claim 57, further comprising:

a integrated light source in at least one floor plate.

68. The dynamic maze according to claim 57, further comprising:

a shock providing mechanism.

69. A dynamic maze, comprising:

at least one removable obstacle wherein the obstacle is under control of a programmable system that configures the maze by inserting the obstacle into the maze or removing the obstacle from the maze and wherein the obstacle transmits a primary stimulus to a test subject in a rewarding or noxious manner, and

a secondary stimulus that can reinforce or conflict with the primary stimulus.

70. A dynamic maze, comprising:

at least one removable obstacle wherein the obstacle is under control of a programmable system that configures the maze by inserting the obstacle into the maze or removing the obstacle from the maze;

a controller having a logic system configured to control design of the maze; and

at least one tube disposed thereon, the tube configured to entrap a test subject such that the test subject can only traverse through the tube in one direction.

71. The maze according to 70, wherein the tube further comprises:

at least one floor plate capable of being an obstacle.

72. The maze according to claim 70, further comprising:

at least one incline means, the incline means configured to be an obstacle to a test subject in the maze such that the incline means is responsive to ability of the test subject to traverse through the maze.

73. The maze according to claim 72, wherein the incline means comprises:

at least one floor plate.

74. The maze according to claim 70, further comprising:

at least one flooring such that the flooring is movable for creating an obstacle for a test subject traversing through the maze.

75. The maze according to claim 70, wherein the flooring further comprises:

at least one stilt that is rotatable about the flooring such that the stilt creates an obstacle for a test subject.

76. The maze according to claim 75, wherein the stilt is adjustable to various angles in relationship to the flooring.

77. The maze according to claim 70, further comprising:

a collapsible flooring, the flooring being able to expose a wall that creates an obstacle for the test subject.

78. The maze according to claim 77, further comprising:

a user interface for manual operation of the collapsible flooring.

79. The maze according to claim 77, wherein the controller controls the collapsible floor based on the behavior of the test subject traversing the maze.