Ionic silver complex

• US 6,838,095 B2
• Filed: 03/07/2003
• Issued: 01/04/2005
• Est. Priority Date: 11/09/1998
• Status: Expired due to Term

• Current Assignee: Ira Jay Newman
• Original Assignee: Ira Jay Newman
• Inventors: Washburn, David, Newman, Ira Jay
• Primary Examiner(s): Clardy, S. Mark
• Assistant Examiner(s): CHOI, FRANK I
• Application Number:
  US10/383,345
• Publication Number:
  US 20030147970A1
• Time in Patent Office: 669 Days
• Field of Search: 424/618, 424/DIG.6, 424/DIG.13, 514/495, 514/561, 514/562, 514/564, 514/565, 514/574, 514/724, 514/784, 514/836, 514/859, 514/912
• US Class Current: 424/618
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/02 containing liquids as carriers, diluents or solvents
• CPC Class Codes: A01N 59/16 Heavy metals; Compounds thereof
• CPC Class Codes: A61K 33/38 Silver; Compounds thereof
• CPC Class Codes: A61K 47/12 Carboxylic acids; Salts or anhydrides thereof
• CPC Class Codes: A61K 47/18 Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/0034 Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears
• CPC Class Codes: A61K 9/0056 Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
• CPC Class Codes: A61K 9/0095 Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006
• CPC Class Codes: A61K 9/08 Solutions composition of solutions A61K47/00
• CPC Class Codes: A61P 1/02 Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61P 17/10 Anti-acne agents
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 31/10 Antimycotics
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61P 31/16 for influenza or rhinoviruses
• CPC Class Codes: Y10S 424/06 Chelate
• CPC Class Codes: Y10S 424/13 : Burn treatment

Abstract

The invention relates to a substantially non-colloidal solution made by combining ingredients comprising (a) water; (b) a source of free silver ions; and (c) a substantially non-toxic, substantially thiol-free, substantially water-soluble complexing agent.

Claims

1. A composition comprising (1) water, (2) a silver complex, wherein the silver complex comprises silver complexed with a complexing agent, and (3) a counter-ion;

wherein the composition is a substantially non-colloidal soultion, wherein the complexing agent is substantially non-toxic, substantially thiol-free, and substantially water-soluble and comprises one or more amino acids and/or hydroxy carboxylic acids;

wherein the molar ratio of complexing agent to silver is greater than one;

wherein the counter-ion comprises one or more alkali metals and/or alkaline earth metals; and

wherein the silver concentration does not exceed about 10,000 ppm.

2. The composition of claim 1, wherein the composition possesses less than ten weight percent of free silver based on the weight of total silver.

3. The composition of claim 1, wherein the composition possesses less than one weight percent of free silver based on the weight of total silver.

4. The composition of claim 1, wherein the composition possesses less than one-tenth of a percent by weight of free silver based on the weight of total silver.

5. The composition of claim 1, wherein the molar ratio of silver to complexing agent is 1:

1.5 to 1;

200.

6. The composition of claim 1, wherein the molar ratio of silver to complexing agent is 1:

1.5 to 1;

50.

7. The composition of claim 1, wherein the molar ratio of silver to complexing agent is 1:

2 to 1;

20.

8. The composition of claim 1, wherein when the complexing agent comprises one or more amino acids, the amino acid comprises glycine, alanine, valine, leucine, isoleucine, methionine, proline, phenylalanine, tryptophan, serine, threonine, tyrosine, asparagine, glutamine, aspartic acid, glutamic acid, lysine, arginine, and/or histidine.

9. The composition of claim 1, wherein when the complexing agent comprises one or more hydroxy carboxylic acids, the hydroxy carboxylic acid comprises glycolic acid, lactic acid, malic acid, tartaric acid, citric acid, and/or mandelic acid.

10. The composition of claim 1, wherein the counter-ion comprises potassium and/or calcium.

11. The composition of claim 1, wherein the silver concentration is about 10 ppm of silver to about 10,000 ppm of silver.

12. The composition of claim 1, wherein the silver concentration is about 20 ppm of silver to about 10,000 ppm of silver.

13. The composition of claim 1, wherein the silver concentration is about 50 ppm of silver to about 10,000 ppm of silver.

14. The composition of claim 1, wherein the silver concentration is about 100 ppm of silver to about 10,000 ppm of silver.

30. A method for treating a disease or condition in a human subject, comprising administering to a human subject in need thereof an effective amount of the composition of any one of claims 1-29, wherein the disease or condition is selected from the group consisting of conjunctivitis, acne, lymphatic cancer, flu, eye infection, burn, urinary tract infection, gum infection and vaginal infection.

15. A composition comprising (1) water, (2) a silver complex, wherein the silver complex comprises silver complexed with citrate, citric acid or a combination thereof, and (3) a counter-ion;

wherein the composition is a substantially non-colloidal soultion;

wherein the complexing agent is substantially non-toxic, substantially thiol-free, and substantially water-soluble;

wherein the molar ratio of complexing agent to silver is greater than one;

wherein the counter-ion comprises one or more alkali metals and/or alkaline earth metals; and

wherein the silver concentration does not exceed about 10,000 ppm.

16. The composition of claim 15, wherein the citrate comprises dibasic citrate.

17. The composition of claim 15, wherein silver is complexed with citric acid and tripotassium citrate.

18. The composition of claim 15, wherein the composition possesses less than ten weight percent of free silver based on the weight of total silver.

19. The composition of claim 15, wherein the composition possesses less than one weight percent of free silver based on the weight of total silver.

20. The composition of claim 15, wherein the composition possesses less than one-tenth of a percent by weight percent of free silver based on the weight of total silver.

21. The composition of claim 15, wherein the molar ratio of silver to citrate, citric acid, or a combination thereof is 1:

1.5 to 1;

200.

22. The composition of claim 15, wherein the molar ratio of silver to citrate, citric acid, or a combination thereof is 1:

1.5 to 1;

50.

23. The composition of claim 15, wherein the molar ratio of silver to citrate, citric acid, or a combination thereof is 1:

2 to 1;

20.

24. The composition of claim 15, wherein the counter-ion comprises potassium and/or calcium.

25. The composition of claim 15, wherein the silver concentration is about 10 ppm of silver to about 10,000 ppm of silver.

26. The composition of claim 15, wherein the silver concentration is about 20 ppm of silver to about 10,000 ppm of silver.

27. The composition of claim 15, wherein the silver concentration is about 50 ppm of silver to about 10,000 ppm of silver.

28. The composition of claim 15, wherein the silver concentration is about 100 ppm of silver to about 10,000 ppm of silver.

29. The composition of claim 15, wherein the counter-ion comprises potassium and/or calcium.