System for normalizing spectra
First Claim
1. A method of performing spectral analysis, the method comprising:
- obtaining an optical spectrum, and normalizing said optical spectrum by application of non-uniform segment normalization, said normalizing step comprising;
selecting one or more segments from said optical spectrum, each of said segments being bounded by an upper wavelength and a lower wavelength and containing one or more wavelengths, each of said wavelengths having an associated amplitude, determining an area under a curve associated with each particular segment, wherein each said curve is bounded along a first axis by said upper wavelength and said lower wavelength of said particular segment, and along a second axis by said amplitudes associated with each of said wavelengths included in said particular segment, summing said areas for each of said segments to determine a normalization factor, and dividing at least one said associated amplitude for one of said wavelengths included in said segments by said normalization factor.
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Abstract
A method and system for normalizing optical spectra using a non-uniform segment normalization. A spectrum is obtained and is represented as a function of wavelength as an amplitude at each of a plurality of wavelengths. At least one segment of the spectrum is selected, each selected segment being bounded by an upper wavelength and a lower wavelength. A normalization factor is computed as the sum of the areas for each of the selected segments. The spectrum is normalized by dividing at least one amplitude of the spectrum by the normalization factor. Segments can be selected with different wavelength ranges, that is, segments can be non-uniform. Test specimens can be categorized based on an analysis of normalized spectra. In particular, the specimen to be tested can be human cervical tissue, and the state of health of the tissue can be determined.
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Citations
19 Claims
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1. A method of performing spectral analysis, the method comprising:
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obtaining an optical spectrum, and normalizing said optical spectrum by application of non-uniform segment normalization, said normalizing step comprising;
selecting one or more segments from said optical spectrum, each of said segments being bounded by an upper wavelength and a lower wavelength and containing one or more wavelengths, each of said wavelengths having an associated amplitude, determining an area under a curve associated with each particular segment, wherein each said curve is bounded along a first axis by said upper wavelength and said lower wavelength of said particular segment, and along a second axis by said amplitudes associated with each of said wavelengths included in said particular segment, summing said areas for each of said segments to determine a normalization factor, and dividing at least one said associated amplitude for one of said wavelengths included in said segments by said normalization factor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A system for performing spectral analysis comprising:
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a spectrographic device adapted to obtain an optical spectrum from a test specimen, a processor adapted to normalize said optical spectrum by application of non-uniform segment normalization, and machine-readable instructions executing on said processor and adapted to;
select one or more segments from said optical spectrum, each of said segments being bounded by an upper wavelength and a lower wavelength, and containing one or more wavelengths, each of said wavelengths having an associated amplitude, determine an area under a curve associated with each particular one of said segments, wherein each said curve is bounded along a first axis by said upper wavelength and said lower wavelength of said particular segment, and along a second axis by said amplitudes associated with each of said wavelengths included in said particular segment, sum said areas for each of said segments to determine a normalization factor, and divide at least one said associated amplitude for one of said wavelengths included in said segments by said normalization factor. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification