Systems and methods for deploying a biosensor with a stent graft

• US 6,840,956 B1
• Filed: 03/10/2000
• Issued: 01/11/2005
• Est. Priority Date: 03/10/2000
• Status: Expired due to Fees

• Current Assignee: Remon Medical Technologies Ltd. (Boston Scientific Corporation)
• Original Assignee: Remon Medical Technologies Ltd. (Boston Scientific Corporation)
• Inventors: Penner, Avi, Wolinsky, Lone
• Primary Examiner(s): BUI, VY Q
• Application Number:
  US09/522,724
• Time in Patent Office: 1,768 Days
• Field of Search: 623/1.11, 623/1.12, 623/1.13, 623/1.14, 623/1.15, 623/1.16, 623/1.17, 623/1.18, 623/1.19, 623/1.2, 623/1.21, 606/191, 606/194, 606/195, 606/198, 600/505, 600/454
• US Class Current: 623/1.13
• CPC Class Codes: A61B 2560/0214 of power generation or supply
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/02014 Determining aneurysm
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/026 Measuring blood flow A61B3/1233, A61B3/1241 take precedence
• CPC Class Codes: A61B 5/076 Permanent implantations telemetry using implanted circuitry A61B5/0031; implanted stimulators for therapy A61N1/3605, A61N1/362, A61N1/372
• CPC Class Codes: A61B 5/11 Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb for measuring pulse A61B5/02 ;A61B5/1038 takes precedence; motion detection to correct for motion artifacts in physiological signals A61B5/721
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/6862 Stents
• CPC Class Codes: A61B 5/6876 Blood vessel

Abstract

A stent graft includes a tubular prosthetic graft, a support structure expandable between contracted and enlarged conditions, and a biosensor attached thereto. The biosensor may be directly attached to an outer surface of the graft, to struts defining the support structure, or by one or more filaments configured to dispose the biosensor beyond an outer surface of the stent graft. When the biosensor is attached by one or more filaments, the stent graft is mounted in a contracted profile on a delivery apparatus with the biosensor disposed adjacent to the stent graft thereon. The stent graft is introduced into a blood vessel in the contracted profile, and advanced endolumenally until it is positioned across an aneurysm. The stent graft is expanded towards an enlarged profile such that ends of the stent graft engage healthy regions of the vessel adjacent to the aneurysm, thereby isolating the aneurysm from the rest of the vessel with the biosensor disposed within the aneurysmal sac, the biosensor allowing remote monitoring of pressure or other conditions to detect an endoleak or excessive pressure therein.

Claims

1. A stent graft, comprising:

a tubular prosthetic graft comprising an outer surface;

a support structure expandable between a contracted condition for facilitating introduction into a blood vessel, and an enlarged condition for securing the graft across a weakened region of the blood vessel; and

an acoustic biosensor attached to at least one of the graft and the expandable support structure, the acoustic biosensor comprising means for converting acoustic energy received from an externally originated signal into a current supply for powering a pressure sensor embedded in the acoustic biosensor, the pressure sensor having at least a portion exposed to a region external to the stent graft to sense pressure beyond the outer surface of the graft within the weakened region of the blood vessel when the graft is secured within the blood vessel.

2. The stent graft of claim 1, wherein the acoustic biosensor is directly attached to an outer surface of the graft such that the pressure sensor is exposed outside the graft.

3. The stent graft of claim 2, wherein the acoustic biosensor is attached to the graft by sutures or an adhesive.

4. The stent graft of claim 1, wherein the acoustic biosensor is directly attached to struts comprising the support structure.

5. The stent graft of claim 1, wherein the support structure comprises a self-expanding stent.

6. The stent graft of claim 1, wherein the support structure comprises a balloon-expandable stent.

7. The stent graft of claim 1, wherein the weakened region of the blood vessel comprises an aneurysmal sac, and the acoustic biosensor is configured for sensing a pressure within the aneurysmal sac when the graft is secured within the blood vessel.

8. The apparatus of claim 4, wherein the support structure is attached to an inner surface of the graft, and wherein the acoustic biosensor is mounted in a hole through the graft such that the pressure sensor is exposed outside the graft.