Coupling to microstructures for a laboratory microchip

• US 6,841,131 B2
• Filed: 11/08/2002
• Issued: 01/11/2005
• Est. Priority Date: 10/01/1999
• Status: Expired due to Fees

• Current Assignee: Agilent Technologies, Inc.
• Original Assignee: Agilent Technologies, Inc.
• Inventors: Plé, Gerhard, Zimmermann, Hans-Peter
• Primary Examiner(s): Warden, Jill
• Assistant Examiner(s): SINES, BRIAN J
• Application Number:
  US10/290,191
• Publication Number:
  US 20030082080A1
• Time in Patent Office: 795 Days
• Field of Search: 422/100, 422/101, 422/102, 422/103, 422/50, 422/55, 422/58, 422/68.1, 422/81, 422/82.05, 73/10.2
• US Class Current: 422/508
• CPC Class Codes: B01L 2200/027 for microfluidic devices
• CPC Class Codes: B01L 2300/0816 Cards, e.g. flat sample carriers usually with flow in two horizontal directions
• CPC Class Codes: B01L 2400/0415 electrical forces, e.g. electrokinetic
• CPC Class Codes: B01L 2400/0622 distribution valves, valves having multiple inlets and/or outlets, e.g. metering valves, multi-way valves
• CPC Class Codes: B01L 2400/0633 with moving parts
• CPC Class Codes: B01L 3/0241 Drop counters; Drop formers making arrays for combinatorial libraries B01J19/0046; automation of dispensing for analysis G01N35/10
• CPC Class Codes: B01L 3/0268 using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
• CPC Class Codes: B01L 3/5027 by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip B01L3/5023 takes precedence; micromixers B01F33/30; microreactors for synthesis B01J19/0093; microcapillary devices in general B81B1/00
• CPC Class Codes: B01L 3/502707 characterised by the manufacture of the container or its components by shaping or joining plastic parts B29C59/00, B29C65/00; by laminating B32B37/00; manufacture of microstructural devices in general B81C
• CPC Class Codes: B01L 3/502715 characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
• CPC Class Codes: B01L 3/502738 characterised by integrated valves microvalves F16K99/0001
• CPC Class Codes: G01N 2035/00247 Microvalves
• CPC Class Codes: G01N 27/44717 Arrangements for investigating the separated zones, e.g. localising zones
• CPC Class Codes: G01N 27/44791 Microapparatus sample containers with integrated microfluidic structures B01L3/5027
• CPC Class Codes: H01J 49/04 Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components

Abstract

What is described in this case is a laboratory microchip having microspray means whose direction of spray can be altered. The microchip has a substrate 40 which has a channel structure provided on one side 41 thereof. On the other side (in the region of an edge of the substrate in the present case), there is a microspray tip 42. Substrate 40 is designed to be deformable particularly in a region 43, in which case the deformability may be achieved either by thinning the substrate material locally in this region 43 or by means of a linear perforation extending approximately perpendicularly to the plane of the paper. Alternatively, the deformability may be obtained by selecting a suitable material for the entire substrate. A microchip which has been bent in the manner indicated is shown in the bottom part of FIG. 3. The bending of the substrate which is shown has turned the direction of spray 44 of microspray tip 42 through 90°. The bending of the substrate may be permanent or reversible in this case.

Claims

1. A microfluidic microchip for chemical, physical, and/or biological analysis of an analyte in a substance comprising a substrate carrying a microfluidic channel structure, the channel structure being arranged so the substance can be moved to follow the channel structure by applying a potential to the channel structure, first and second portions of the channel structure being respectively parts of first and second sections of the substrate, the second section channel structure being deformable with respect to the first section channel structure, the first section channel structure being arranged to be responsive to the substance, the second section channel structure including an outlet for delivering the substance to an analyzer of the substance.

2. The microchip of claim 1 wherein the deformable section of the substrate carrying the portion of the channel structure is bendable.

3. The microchip of claim 1 wherein the deformable section of the substrate carrying the portion of the channel structure is foldable.

4. The microchip of claim 1 wherein the deformable section of the substrate carrying the portion of the channel structure is elastically, anelastically or plastically deformable.

5. The microchip of claim 1 wherein the channel structure includes an arrangement for enabling the substance to be coupled to at least one substance transporting system positioned on and/or off the microchip.

6. The microchip of claim 1 wherein the entire substrate is bendable and has a thickness in the range of between approximately 10 μ

m and approximately 1 mm.

7. The microchip of claim 6 wherein the substrate is formed from an elastically, anelastically or plastically deformable plastic material.

8. The microchip of claim 1 wherein the deformable section of the substrate carrying the portion of the channel structure includes a bendable channel section having a substance-conveying connection to at least two other channel sections of the substrate.

12. The microchip of claim 1 wherein the segment for delivering and the second portion are bendable relative to each other so the second segment is pivotable relative to a point on a channel segment in the first portion, the channel segment in the first portion being arranged for enabling the analyte to flow past the point.

13. The microchip of claim 12 wherein the first and second portions of the channel structure are pivotable about a point in a plane including said channel segment in the first portion.

14. The microchip of claim 13 wherein the segment of the second section is arranged for delivering the substance to plural substance sumps located in different planes having a non-zero angle with respect to said channel segment in the first portion.

15. The microchip of claim 14 wherein the second section channel structure includes a plurality of segments for selectively delivering to one substance sump the substance in said channel segment in the first portion.

16. The microchip of claim 1 wherein the segment in the second section includes an optically transparent region between an optical source and an optical detector of the analyzer.

18. The microchip of claim 1 wherein the substrate, including the first and second section channel structures, is monolithic.

9. A microfluidic microchip for chemical, physical, and/or biological analysis of an analyte in a substance comprising a substrate carrying a microfluidic channel structure, the channel structure being arranged so the substance can be moved to follow the channel structure by applying a potential to the channel structure, first and second portions of the channel structure being respectively parts of first and second sections of the substrate, the first and second section channel structures being in different planes having a non-zero angle with respect to each other the first section channel structure being arranged to be responsive to the substance, the second section channel structure including a segment for delivering the substance to an analyzer of the substance.

10. The microchip of claim 9 wherein the potential is electrical.

11. The microchip of claim 9 wherein the potential is fluidic.

17. The microchip of claim 9 wherein the substrate, including the first and second section channel structures, is monolithic.

19. A microfluidic microchip for transporting a substance comprising a substrate carrying a microfluidic channel structure, the channel structure being arranged so the substance can be moved to follow the channel structure by applying a potential to the channel structure, first and second portions of the channel structure being respectively parts of first and second sections of the substrate, the second section channel structure being deformable with respect to the first section channel structure, the first section channel structure being arranged to be responsive to the substance and to couple the substance to the second section channel structure while the second section channel structure is deformed with respect to the first section channel structure.

20. The microchip of claim 19 wherein the substrate, including the first and second section channel structures, is monolithic.

21. The microchip of claim 19 wherein the second section channel structure is bendable with respect to the first section channel structure and the first section channel structure is arranged to couple the substance to the second section channel structure while the first section channel structure is bent with respect to the second section channel structure.

22. The microchip of claim 19 wherein the second section channel structure is foldable with respect to the first section channel structure and the first section channel structure is arranged to couple the substance to the second section channel structure while the second section channel structure is folded with respect to the first section channel structure.

23. The microchip of claim 19 in combination with an analyzer for an analyte in the substance, the analyzer being positioned and arranged to be responsive to substance transported in the second channel structure.

24. The microchip of claim 19 wherein the second section channel structure is deformed with respect to the first section channel structure.

25. The microchip of claim 21 wherein the second section channel structure is bent with respect to the first section channel structure.

26. The microchip of claim 22 wherein the second section channel structure is folded with respect to the first section channel structure.